Exosome‐mediated transfer of miR‐1260b promotes cell invasion through Wnt/β–catenin signaling pathway in lung adenocarcinoma

Increasing evidence confirms that exosome‐mediated transfer of microRNAs can influence cancer progression including tumor cell invasion, cell proliferation, and drug resistance via cell–cell communication. However, the potential role of exosomal‐miR‐1260b in lung adenocarcinoma (LAC) remains poorly...

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Veröffentlicht in:	Journal of cellular physiology 2020-10, Vol.235 (10), p.6843-6853
Hauptverfasser:	Xia, Yang, Wei, Ke, Hu, Liu‐Qing, Zhou, Cun‐Rong, Lu, Zhi‐Bin, Zhan, Gen‐Sheng, Pan, Xiang‐Long, Pan, Chun‐Feng, Wang, Jun, Wen, Wei, Xu, Jing, He, Zhi‐Cheng, Huang, Chen‐Jun, Chen, Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Adenocarcinoma Adenocarcinoma of Lung - genetics Adenocarcinoma of Lung - pathology beta Catenin - genetics Biosynthesis Catenin Cell interactions Cell Line, Tumor Cell Movement - genetics Cell proliferation Cell Proliferation - genetics Ceramide Ceramides - genetics Drug resistance exosomal‐miR‐1260b Exosomes - genetics Female Frizzled-related protein 1 Gene Expression Regulation, Neoplastic - genetics Humans lung adenocarcinoma Lung cancer Lung Neoplasms - genetics Lung Neoplasms - pathology Lungs Male Membrane Proteins - genetics MicroRNAs MicroRNAs - genetics Middle Aged miRNA Polymerase chain reaction sFRP1 Signal transduction Signal Transduction - genetics Signaling Smad4 Smad4 protein Smad4 Protein - genetics Tumors Wnt protein Wnt Signaling Pathway - genetics Wnt/β‐catenin
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