Exosome‐mediated transfer of miR‐1260b promotes cell invasion through Wnt/β–catenin signaling pathway in lung adenocarcinoma

Increasing evidence confirms that exosome‐mediated transfer of microRNAs can influence cancer progression including tumor cell invasion, cell proliferation, and drug resistance via cell–cell communication. However, the potential role of exosomal‐miR‐1260b in lung adenocarcinoma (LAC) remains poorly understood. Thus, this study focused on investigating the function of exosomal‐miR‐1260b on cell invasion. Exosomal‐miR‐1260b was found to be higher in plasma of patients with LAC than that of healthy persons via quantitative real‐time polymerase chain reaction assay. The sensitivity and specificity of exosomal‐miR‐1260b (cutoff point: 2.027) were 72% and 86%, and area under the curve of 0.845 (95% CI = 0.772–0.922). Elevated expression of miR‐1260b in LAC tissues was positively correlated with exosomal‐miR‐1260b in plasma (r = .642, p