Epigenetic Modulation of the Tumor Immune Microenvironment to Potentiate Immune Checkpoint Blockade Therapy

Epigenetic Modulation of the Tumor Immune Microenvironment to Potentiate Immune Checkpoint Blockade Therapy

Response rates to immune checkpoint blockade (ICB) in KRAS-mutant lung adenocarcinoma remain poor. In this issue of , Li and colleagues report an CRISPR screen of epigenetic regulators of the tumor immune microenvironment that uncovers as a tumor-intrinsic suppressor of ICB through suppression of GM...

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Veröffentlicht in:Cancer discovery 2020-02, Vol.10 (2), p.179-181
Hauptverfasser: Menzel, Johannes, Black, Joshua C
Format: Artikel
Sprache:eng
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Zusammenfassung:Response rates to immune checkpoint blockade (ICB) in KRAS-mutant lung adenocarcinoma remain poor. In this issue of , Li and colleagues report an CRISPR screen of epigenetic regulators of the tumor immune microenvironment that uncovers as a tumor-intrinsic suppressor of ICB through suppression of GM-CSF expression. .
ISSN:2159-8274
2159-8290
DOI:10.1158/2159-8290.CD-19-1349