Study on the relationship between FFA and gout flare
Objectives To detect the serum free fatty acid (FFA) concentration in patients with primary gouty arthritis (GA) and to explore the correlation between FFA and gout flare. Method Sixty patients with acute GA, 60 patients with GA remission, 60 patients with asymptomatic hyperuricemia (HUA), and 60 no...
Gespeichert in:
| Veröffentlicht in: | Clinical rheumatology 2020-04, Vol.39 (4), p.1251-1255 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1255 |
|---|---|
| container_issue | 4 |
| container_start_page | 1251 |
| container_title | Clinical rheumatology |
| container_volume | 39 |
| creator | Pei, Lin Xie, Linfeng Wu, Junying Zhang, Han Zhang, Xuewu |
| description | Objectives
To detect the serum free fatty acid (FFA) concentration in patients with primary gouty arthritis (GA) and to explore the correlation between FFA and gout flare.
Method
Sixty patients with acute GA, 60 patients with GA remission, 60 patients with asymptomatic hyperuricemia (HUA), and 60 normal controls were enrolled in this study. Serum FFA concentration was detected by enzymatic determination in four groups, and the relationship between serum FFA, serum urate (SU), and other clinical and laboratory parameters was analyzed.
Results
(1) Serum FFA concentration was significantly higher in the acute GA than in the GA remission, the asymptomatic HUA, and the normal control (
H
= 72.191,
P
|
| doi_str_mv | 10.1007/s10067-019-04903-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2350901634</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2387553548</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-1fee148139b44c663a3b6ed143170311c9932c5eb588dd7ba4c92d12a12ba9003</originalsourceid><addsrcrecordid>eNp9kD1PwzAQhi0EoqXwBxhQJBYWw_krjscKUUCqxADMlpNc-qE0KXYi1H-PIQUkBhbf4Ofeu3sIOWdwzQD0TYhvqikwQ0EaENQckDGTQlJjpDkkY9AaqGAmG5GTENYAwDPDjslIcGBpquSYyOeuL3dJ2yTdEhOPtetWbROWq22SY_eO2CSz2TRxTZks2r5Lqtp5PCVHlasDnu3rhLzO7l5uH-j86f7xdjqnhdCqo6xCZDJjwuRSFmkqnMhTLOOGTINgrDBG8EJhrrKsLHXuZGF4ybhjPHcGQEzI1ZC79e1bj6Gzm1UosK5dg20fLBcKTLxEyIhe_kHXbe-buF2kMq2UUDKLFB-owrcheKzs1q82zu8sA_vp1A5ObXRqv5xaE5su9tF9vsHyp-VbYgTEAIT41SzQ_87-J_YDNcR-pA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2387553548</pqid></control><display><type>article</type><title>Study on the relationship between FFA and gout flare</title><source>MEDLINE</source><source>SpringerLink (Online service)</source><creator>Pei, Lin ; Xie, Linfeng ; Wu, Junying ; Zhang, Han ; Zhang, Xuewu</creator><creatorcontrib>Pei, Lin ; Xie, Linfeng ; Wu, Junying ; Zhang, Han ; Zhang, Xuewu</creatorcontrib><description>Objectives
To detect the serum free fatty acid (FFA) concentration in patients with primary gouty arthritis (GA) and to explore the correlation between FFA and gout flare.
Method
Sixty patients with acute GA, 60 patients with GA remission, 60 patients with asymptomatic hyperuricemia (HUA), and 60 normal controls were enrolled in this study. Serum FFA concentration was detected by enzymatic determination in four groups, and the relationship between serum FFA, serum urate (SU), and other clinical and laboratory parameters was analyzed.
Results
(1) Serum FFA concentration was significantly higher in the acute GA than in the GA remission, the asymptomatic HUA, and the normal control (
H
= 72.191,
P
< 0.001). (2) There were no significant difference in serum triglyceride and low-density lipoprotein cholesterol (LDL-C) concentration between the acute GA, the GA remission, the asymptomatic HUA, and the normal control group.
Conclusions
FFA may be involved in the acute attack of gout in conditions of monosodium urate crystal deposition in the joints. Triglyceride and LDL-C may not be involved in the acute attack of gout. FFA may be used as an indicator to monitor the status of GA in clinical.
Key Points
• Lin Pei and Linfeng Xie designed the randomized controlled trial and were responsible for the development of the protocol.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-019-04903-9</identifier><identifier>PMID: 32016654</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Arthritis ; Arthritis, Gouty - diagnosis ; Biomarkers - blood ; Cholesterol ; Cholesterol, LDL - blood ; Fatty Acids, Nonesterified - blood ; Female ; Gout ; Gout - blood ; Gout - diagnosis ; Gout - etiology ; Humans ; Hyperuricemia ; Hyperuricemia - blood ; Hyperuricemia - diagnosis ; Joint diseases ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Remission ; Rheumatology ; Symptom Flare Up ; Triglycerides - blood ; Uric acid ; Uric Acid - blood ; Young Adult</subject><ispartof>Clinical rheumatology, 2020-04, Vol.39 (4), p.1251-1255</ispartof><rights>International League of Associations for Rheumatology (ILAR) 2020</rights><rights>International League of Associations for Rheumatology (ILAR) 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-1fee148139b44c663a3b6ed143170311c9932c5eb588dd7ba4c92d12a12ba9003</citedby><cites>FETCH-LOGICAL-c375t-1fee148139b44c663a3b6ed143170311c9932c5eb588dd7ba4c92d12a12ba9003</cites><orcidid>0000-0002-6347-1200</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10067-019-04903-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10067-019-04903-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32016654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pei, Lin</creatorcontrib><creatorcontrib>Xie, Linfeng</creatorcontrib><creatorcontrib>Wu, Junying</creatorcontrib><creatorcontrib>Zhang, Han</creatorcontrib><creatorcontrib>Zhang, Xuewu</creatorcontrib><title>Study on the relationship between FFA and gout flare</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>Objectives
To detect the serum free fatty acid (FFA) concentration in patients with primary gouty arthritis (GA) and to explore the correlation between FFA and gout flare.
Method
Sixty patients with acute GA, 60 patients with GA remission, 60 patients with asymptomatic hyperuricemia (HUA), and 60 normal controls were enrolled in this study. Serum FFA concentration was detected by enzymatic determination in four groups, and the relationship between serum FFA, serum urate (SU), and other clinical and laboratory parameters was analyzed.
Results
(1) Serum FFA concentration was significantly higher in the acute GA than in the GA remission, the asymptomatic HUA, and the normal control (
H
= 72.191,
P
< 0.001). (2) There were no significant difference in serum triglyceride and low-density lipoprotein cholesterol (LDL-C) concentration between the acute GA, the GA remission, the asymptomatic HUA, and the normal control group.
Conclusions
FFA may be involved in the acute attack of gout in conditions of monosodium urate crystal deposition in the joints. Triglyceride and LDL-C may not be involved in the acute attack of gout. FFA may be used as an indicator to monitor the status of GA in clinical.
Key Points
• Lin Pei and Linfeng Xie designed the randomized controlled trial and were responsible for the development of the protocol.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arthritis</subject><subject>Arthritis, Gouty - diagnosis</subject><subject>Biomarkers - blood</subject><subject>Cholesterol</subject><subject>Cholesterol, LDL - blood</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Female</subject><subject>Gout</subject><subject>Gout - blood</subject><subject>Gout - diagnosis</subject><subject>Gout - etiology</subject><subject>Humans</subject><subject>Hyperuricemia</subject><subject>Hyperuricemia - blood</subject><subject>Hyperuricemia - diagnosis</subject><subject>Joint diseases</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Remission</subject><subject>Rheumatology</subject><subject>Symptom Flare Up</subject><subject>Triglycerides - blood</subject><subject>Uric acid</subject><subject>Uric Acid - blood</subject><subject>Young Adult</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kD1PwzAQhi0EoqXwBxhQJBYWw_krjscKUUCqxADMlpNc-qE0KXYi1H-PIQUkBhbf4Ofeu3sIOWdwzQD0TYhvqikwQ0EaENQckDGTQlJjpDkkY9AaqGAmG5GTENYAwDPDjslIcGBpquSYyOeuL3dJ2yTdEhOPtetWbROWq22SY_eO2CSz2TRxTZks2r5Lqtp5PCVHlasDnu3rhLzO7l5uH-j86f7xdjqnhdCqo6xCZDJjwuRSFmkqnMhTLOOGTINgrDBG8EJhrrKsLHXuZGF4ybhjPHcGQEzI1ZC79e1bj6Gzm1UosK5dg20fLBcKTLxEyIhe_kHXbe-buF2kMq2UUDKLFB-owrcheKzs1q82zu8sA_vp1A5ObXRqv5xaE5su9tF9vsHyp-VbYgTEAIT41SzQ_87-J_YDNcR-pA</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Pei, Lin</creator><creator>Xie, Linfeng</creator><creator>Wu, Junying</creator><creator>Zhang, Han</creator><creator>Zhang, Xuewu</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6347-1200</orcidid></search><sort><creationdate>20200401</creationdate><title>Study on the relationship between FFA and gout flare</title><author>Pei, Lin ; Xie, Linfeng ; Wu, Junying ; Zhang, Han ; Zhang, Xuewu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-1fee148139b44c663a3b6ed143170311c9932c5eb588dd7ba4c92d12a12ba9003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arthritis</topic><topic>Arthritis, Gouty - diagnosis</topic><topic>Biomarkers - blood</topic><topic>Cholesterol</topic><topic>Cholesterol, LDL - blood</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Female</topic><topic>Gout</topic><topic>Gout - blood</topic><topic>Gout - diagnosis</topic><topic>Gout - etiology</topic><topic>Humans</topic><topic>Hyperuricemia</topic><topic>Hyperuricemia - blood</topic><topic>Hyperuricemia - diagnosis</topic><topic>Joint diseases</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Remission</topic><topic>Rheumatology</topic><topic>Symptom Flare Up</topic><topic>Triglycerides - blood</topic><topic>Uric acid</topic><topic>Uric Acid - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pei, Lin</creatorcontrib><creatorcontrib>Xie, Linfeng</creatorcontrib><creatorcontrib>Wu, Junying</creatorcontrib><creatorcontrib>Zhang, Han</creatorcontrib><creatorcontrib>Zhang, Xuewu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pei, Lin</au><au>Xie, Linfeng</au><au>Wu, Junying</au><au>Zhang, Han</au><au>Zhang, Xuewu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study on the relationship between FFA and gout flare</atitle><jtitle>Clinical rheumatology</jtitle><stitle>Clin Rheumatol</stitle><addtitle>Clin Rheumatol</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>39</volume><issue>4</issue><spage>1251</spage><epage>1255</epage><pages>1251-1255</pages><issn>0770-3198</issn><eissn>1434-9949</eissn><abstract>Objectives
To detect the serum free fatty acid (FFA) concentration in patients with primary gouty arthritis (GA) and to explore the correlation between FFA and gout flare.
Method
Sixty patients with acute GA, 60 patients with GA remission, 60 patients with asymptomatic hyperuricemia (HUA), and 60 normal controls were enrolled in this study. Serum FFA concentration was detected by enzymatic determination in four groups, and the relationship between serum FFA, serum urate (SU), and other clinical and laboratory parameters was analyzed.
Results
(1) Serum FFA concentration was significantly higher in the acute GA than in the GA remission, the asymptomatic HUA, and the normal control (
H
= 72.191,
P
< 0.001). (2) There were no significant difference in serum triglyceride and low-density lipoprotein cholesterol (LDL-C) concentration between the acute GA, the GA remission, the asymptomatic HUA, and the normal control group.
Conclusions
FFA may be involved in the acute attack of gout in conditions of monosodium urate crystal deposition in the joints. Triglyceride and LDL-C may not be involved in the acute attack of gout. FFA may be used as an indicator to monitor the status of GA in clinical.
Key Points
• Lin Pei and Linfeng Xie designed the randomized controlled trial and were responsible for the development of the protocol.</abstract><cop>London</cop><pub>Springer London</pub><pmid>32016654</pmid><doi>10.1007/s10067-019-04903-9</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-6347-1200</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0770-3198 |
| ispartof | Clinical rheumatology, 2020-04, Vol.39 (4), p.1251-1255 |
| issn | 0770-3198 1434-9949 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2350901634 |
| source | MEDLINE; SpringerLink (Online service) |
| subjects | Adult Aged Aged, 80 and over Arthritis Arthritis, Gouty - diagnosis Biomarkers - blood Cholesterol Cholesterol, LDL - blood Fatty Acids, Nonesterified - blood Female Gout Gout - blood Gout - diagnosis Gout - etiology Humans Hyperuricemia Hyperuricemia - blood Hyperuricemia - diagnosis Joint diseases Male Medicine Medicine & Public Health Middle Aged Original Article Remission Rheumatology Symptom Flare Up Triglycerides - blood Uric acid Uric Acid - blood Young Adult |
| title | Study on the relationship between FFA and gout flare |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T06%3A36%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Study%20on%20the%20relationship%20between%20FFA%20and%20gout%20flare&rft.jtitle=Clinical%20rheumatology&rft.au=Pei,%20Lin&rft.date=2020-04-01&rft.volume=39&rft.issue=4&rft.spage=1251&rft.epage=1255&rft.pages=1251-1255&rft.issn=0770-3198&rft.eissn=1434-9949&rft_id=info:doi/10.1007/s10067-019-04903-9&rft_dat=%3Cproquest_cross%3E2387553548%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2387553548&rft_id=info:pmid/32016654&rfr_iscdi=true |