Optimizing planning CT using past CT images for prostate cancer volumetric modulated arc therapy

This study aimed to evaluate a new method to optimize planning computed tomography (CT) using three-dimensional (3D) displacement error between the planning and diagnosed past CT scans. Thirty-two patients undergoing volumetric modulated arc therapy for prostate cancer were evaluated for a 3D displacement error between bone- and prostate-matching spatial coordinates using multiple acquisition planning CT (MPCT) scans. Each MPCT image and a past CT image were used to perform rigid image registration (RIR) and deformable image registration (DIR), and the 3D displacement error was calculated. Correlations of the 3D displacement error in each MPCT scan and between the MPCT and past CT were evaluated based on RIR and DIR, respectively. The 3D displacement error in the MPCT images exhibited moderate correlation with the 3D displacement error between MPCT and past CT for both RIR (adjusted r2 = 0.495) and DIR (adjusted r2 = 0.398). In the correlation analysis between MPCT and past CT, image pairs with 3D displacement errors ≥ 6 mm were significantly different from those with errors < 6 mm (p < 0.0001). Past CT images were different from the planning CT images, which can be attributed to setup tools, flat-top plates, and physical differences due to the presence or absence of urine as well as prescription effects. The relationship between bone and prostate exhibited small deviations between the planning and past CT regardless of pretreatment. The prostate, which only has a slight effect on the displacement between it and bladder volume, was covered with a stiff pelvic bone. As a result, MPCT images exhibited correlations with past CT images of various difference states such as body positions. Finally, large 3D displacement errors in prostate position were caused by pelvic tension and stress, which can be detected using diagnosed past CT images instead of requiring MPCT scans. By comparing past and planning CT images, the random displacement error in the planning CT scan can be avoided by evaluating 3D displacement errors. The new method using the past CT images can estimate the displacement error of the prostate during the treatment period with 1 plan CT scan only, and it helps improve the treatment accuracy.