Association of cognitive and P50 suppression deficits in chronic patients with schizophrenia

•We compared cognition and P50 sensory gating in 38 schizophrenia and 32 controls.•Patients showed higher P50 gating ratio and S2 amplitude but lower S1 amplitude.•S1 or S2 amplitude was possibly correlated with some cognitive domains in patients. Cognitive deficits are core symptoms of schizophrenia; however, their pathophysiological mechanisms are still unclear. A sensory gating deficit, as reflected by P50 suppression, has been repeatedly shown in schizophrenia patients, which may be associated with cognitive deficits in this disorder. The present study was to examine the relationship between the P50 suppression and cognitive deficits in patients with schizophrenia, which is still under-investigated. We recruited 38 chronic schizophrenia patients and 32 matched healthy controls, and assessed their cognition with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and P50 suppression with the electroencephalography system. The total and its 4 index scores (all p