Impact of serum omentin-1 concentrations on functional outcome among acute intracerebral hemorrhage patients

•Reduced serum omentin-1 levels in intracerebral hemorrhage patients with a poor outcome.•Inverse correlation of serum omentin-1 levels with hemorrhagic severity.•Independent association of serum omentin-1 levels with 90-day functional outcome. Reduced serum omentin-1 concentrations might be related...

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Veröffentlicht in:Clinica chimica acta 2020-04, Vol.503, p.169-174
Hauptverfasser: Zhang, Guo-Hai, Ye, Zhe-Hao, Guan, Hao-Jie, Guo, Mi, Zhou, Xin-Xiang, Xu, Yu-Yu
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Sprache:eng
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Zusammenfassung:•Reduced serum omentin-1 levels in intracerebral hemorrhage patients with a poor outcome.•Inverse correlation of serum omentin-1 levels with hemorrhagic severity.•Independent association of serum omentin-1 levels with 90-day functional outcome. Reduced serum omentin-1 concentrations might be related to an increased risk for poor functional outcome after acute ischemic stroke. We intended to explore whether serum omentin-1 could be a promising prognostic biomarker for acute intracerebral hemorrhage. A total of 104 consecutive patients with hemorrhagic stroke underwent 90-day follow-up. The modified Rankin scale score >2 was evaluated as worse prognosis. A multivariable logistic model was conFig.d for assessing the relationship between serum omentin-1 concentrations and functional outcome. Serum omentin-1 concentrations, with the median value of 147.9 ng/ml (interquartile range, 114.7–199.8 ng/ml), were substantially declined with rising modified Rankin scale scores (P 
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2020.01.026