Crescentic IgA nephropathy in children
Objectives Crescentic IgA nephropathy (C-IgAN) is defined as IgAN with more than 50% of glomeruli showing crescents. C-IgAN in children is rare; we investigate in detail for the first time. Methods We retrospectively analyzed the 515 consecutive children who were newly diagnosed with biopsy-proven I...
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Veröffentlicht in: | Pediatric nephrology (Berlin, West) West), 2020-06, Vol.35 (6), p.1005-1014 |
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Hauptverfasser: | , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Objectives
Crescentic IgA nephropathy (C-IgAN) is defined as IgAN with more than 50% of glomeruli showing crescents. C-IgAN in children is rare; we investigate in detail for the first time.
Methods
We retrospectively analyzed the 515 consecutive children who were newly diagnosed with biopsy-proven IgAN between June 1976 and May 2010. We compared clinical and pathological findings between C-IgAN and non-C-IgAN.
Results
Among 515 cases of childhood IgAN, 25 children (4.9%) had C-IgAN. Of these 25, 16 children (64%) were referred to hospitals by annual school screening. Clinical findings showed significant differences in gross hematuria (76 vs. 50%,
p
= .03), excretion of proteinuria (1.9 vs. 0.5 g/day/m
2
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p
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ISSN: | 0931-041X 1432-198X |
DOI: | 10.1007/s00467-020-04483-w |