Ketone-Directed Cobalt(III)-Catalyzed Regioselective C2 Amidation of Indoles

Ketone-Directed Cobalt(III)-Catalyzed Regioselective C2 Amidation of Indoles

An efficient cobalt­(III)-catalyzed method for the direct C–H amidation of unprotected indoles for 2-amino indole scaffold construction has been developed. With dioxazolone as the amidating reagent, a variety of 2-amino indole derivatives were achieved in moderate to excellent yields using an organi...

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Veröffentlicht in:Journal of organic chemistry 2020-03, Vol.85 (5), p.3911-3920
Hauptverfasser: Shi, Xinxia, Xu, Weiyan, Wang, Rongchao, Zeng, Xiaofei, Qiu, Huayu, Wang, Min
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container_issue 5
container_start_page 3911
container_title Journal of organic chemistry
container_volume 85
creator Shi, Xinxia
Xu, Weiyan
Wang, Rongchao
Zeng, Xiaofei
Qiu, Huayu
Wang, Min
description An efficient cobalt­(III)-catalyzed method for the direct C–H amidation of unprotected indoles for 2-amino indole scaffold construction has been developed. With dioxazolone as the amidating reagent, a variety of 2-amino indole derivatives were achieved in moderate to excellent yields using an organic acid as the additive and a ketone as the directing group.
doi_str_mv 10.1021/acs.joc.9b03018
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title Ketone-Directed Cobalt(III)-Catalyzed Regioselective C2 Amidation of Indoles
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