Ketone-Directed Cobalt(III)-Catalyzed Regioselective C2 Amidation of Indoles

Ketone-Directed Cobalt(III)-Catalyzed Regioselective C2 Amidation of Indoles

An efficient cobalt­(III)-catalyzed method for the direct C–H amidation of unprotected indoles for 2-amino indole scaffold construction has been developed. With dioxazolone as the amidating reagent, a variety of 2-amino indole derivatives were achieved in moderate to excellent yields using an organi...

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Veröffentlicht in:Journal of organic chemistry 2020-03, Vol.85 (5), p.3911-3920
Hauptverfasser: Shi, Xinxia, Xu, Weiyan, Wang, Rongchao, Zeng, Xiaofei, Qiu, Huayu, Wang, Min
Format: Artikel
Sprache:eng
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Zusammenfassung:An efficient cobalt­(III)-catalyzed method for the direct C–H amidation of unprotected indoles for 2-amino indole scaffold construction has been developed. With dioxazolone as the amidating reagent, a variety of 2-amino indole derivatives were achieved in moderate to excellent yields using an organic acid as the additive and a ketone as the directing group.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.9b03018