Anti-inflammatory and antioxidant activity of hydroethanolic extract of Spondias mombin leaf in an oral mucositis experimental model
•The animals treated with HESM at a dose of 200 mg/kg exhibited almost complete healing in all animals.•The HESM (200 mg/kg) group revealed a large amount of collagen fibers, which presented greater healing and granular tissue formation in the oral mucositis area.•MDA levels were lower in the HESM (...
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| Veröffentlicht in: | Archives of oral biology 2020-03, Vol.111, p.104664-104664, Article 104664 |
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| creator | Sousa Gomes, Mayra Diógenes Alves Uchoa Lins, Ruthineia Zucolotto Langassner, Silvana Maria Dantas da Silveira, Éricka Janine Gomes de Carvalho, Thais Diniz de Sousa Lopes, Maria Luiza de Souza Araújo, Lorena Addison Carvalho Xavier de Medeiros, Caroline Ferreira de Carvalho Leitão, Renata Coelho Bernardo Guerra, Gerlane Fernandes de Araújo Junior, Raimundo Antunes de Araújo, Aurigena |
| description | •The animals treated with HESM at a dose of 200 mg/kg exhibited almost complete healing in all animals.•The HESM (200 mg/kg) group revealed a large amount of collagen fibers, which presented greater healing and granular tissue formation in the oral mucositis area.•MDA levels were lower in the HESM (200 mg/kg) group when compared to that observed in the 5FU/MT group (p |
| doi_str_mv | 10.1016/j.archoralbio.2020.104664 |
| format | Article |
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Spondias mombin has been used in folk medicine to treat inflammation in the oral cavity. This study aimed to evaluate the antioxidant and anti-inflammatory activity of S. mombin extract in an oral mucositis experimental model.
Male hamsters were orally pre-treated with hydroethanolic extract of S. mombin leaves (HESM) (50, 100, or 200 mg/kg) for ten days. Cheek pouch samples were subjected to macroscopic, histopathological and immunohistochemical analysis (Cox-2, iNOS, NF-kB p50 NLS and MMP-2). IL-1β and TNF-α levels were analyzed by ELISA immunoassay, and Superoxide dismutase estimative (SOD), glutathione (GSH) and malondialdehyde (MDA) levels were submitted to spectroscopy analysis.
The group treated with HESM at a dose of 200 mg/kg showed the best healing effect, showing no evidence of ulceration in the macroscopic analysis (p < 0.05). Histopathological analysis showed re-epithelialization, discrete mononuclear inflammatory infiltrate and absence of hemorrhage and edema score of 1 (1-1) (p < 0.05), as well as a large amount of collagen fibers and a lower immunoexpression of Cox-2, iNOS, NF-kB p50 NLS and MMP-2. Decrease in SOD (p < 0.05), MDA (p<0.001), IL-1β (p < 0.05), and TNF-α levels (p < 0.001), with an increase in GSH (p < 0.01) levels.
HESM (200 mg/kg) reduced oxidative stress and inflammation in the 5-fluorouracil-induced oral mucositis in hamsters.]]></description><identifier>ISSN: 0003-9969</identifier><identifier>EISSN: 1879-1506</identifier><identifier>DOI: 10.1016/j.archoralbio.2020.104664</identifier><identifier>PMID: 31982600</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>5-Fluorouracil ; Anacardiaceae - chemistry ; Animals ; Anti-Inflammatory Agents - pharmacology ; Antioxidants - pharmacology ; Cricetinae ; Dentistry ; Inflammation ; Male ; Oral mucositis ; Oxidative Stress ; Plant Extracts - pharmacology ; Plant Leaves - chemistry ; Spondias mombin ; Stomatitis - drug therapy</subject><ispartof>Archives of oral biology, 2020-03, Vol.111, p.104664-104664, Article 104664</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-55cee56def1d72d5bc7ffb84650b96cf71f7d249baed825b8be2d7f8843765fd3</citedby><cites>FETCH-LOGICAL-c428t-55cee56def1d72d5bc7ffb84650b96cf71f7d249baed825b8be2d7f8843765fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0003996919311513$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31982600$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sousa Gomes, Mayra</creatorcontrib><creatorcontrib>Diógenes Alves Uchoa Lins, Ruthineia</creatorcontrib><creatorcontrib>Zucolotto Langassner, Silvana Maria</creatorcontrib><creatorcontrib>Dantas da Silveira, Éricka Janine</creatorcontrib><creatorcontrib>Gomes de Carvalho, Thais</creatorcontrib><creatorcontrib>Diniz de Sousa Lopes, Maria Luiza</creatorcontrib><creatorcontrib>de Souza Araújo, Lorena</creatorcontrib><creatorcontrib>Addison Carvalho Xavier de Medeiros, Caroline</creatorcontrib><creatorcontrib>Ferreira de Carvalho Leitão, Renata</creatorcontrib><creatorcontrib>Coelho Bernardo Guerra, Gerlane</creatorcontrib><creatorcontrib>Fernandes de Araújo Junior, Raimundo</creatorcontrib><creatorcontrib>Antunes de Araújo, Aurigena</creatorcontrib><title>Anti-inflammatory and antioxidant activity of hydroethanolic extract of Spondias mombin leaf in an oral mucositis experimental model</title><title>Archives of oral biology</title><addtitle>Arch Oral Biol</addtitle><description><![CDATA[•The animals treated with HESM at a dose of 200 mg/kg exhibited almost complete healing in all animals.•The HESM (200 mg/kg) group revealed a large amount of collagen fibers, which presented greater healing and granular tissue formation in the oral mucositis area.•MDA levels were lower in the HESM (200 mg/kg) group when compared to that observed in the 5FU/MT group (p < 0.001).•Inflammatory cytokine IL-1β was significantly lower in the HESM (200 mg/kg) group (p < 0.05) compared to 5FU/MT group.
Spondias mombin has been used in folk medicine to treat inflammation in the oral cavity. This study aimed to evaluate the antioxidant and anti-inflammatory activity of S. mombin extract in an oral mucositis experimental model.
Male hamsters were orally pre-treated with hydroethanolic extract of S. mombin leaves (HESM) (50, 100, or 200 mg/kg) for ten days. Cheek pouch samples were subjected to macroscopic, histopathological and immunohistochemical analysis (Cox-2, iNOS, NF-kB p50 NLS and MMP-2). IL-1β and TNF-α levels were analyzed by ELISA immunoassay, and Superoxide dismutase estimative (SOD), glutathione (GSH) and malondialdehyde (MDA) levels were submitted to spectroscopy analysis.
The group treated with HESM at a dose of 200 mg/kg showed the best healing effect, showing no evidence of ulceration in the macroscopic analysis (p < 0.05). Histopathological analysis showed re-epithelialization, discrete mononuclear inflammatory infiltrate and absence of hemorrhage and edema score of 1 (1-1) (p < 0.05), as well as a large amount of collagen fibers and a lower immunoexpression of Cox-2, iNOS, NF-kB p50 NLS and MMP-2. Decrease in SOD (p < 0.05), MDA (p<0.001), IL-1β (p < 0.05), and TNF-α levels (p < 0.001), with an increase in GSH (p < 0.01) levels.
HESM (200 mg/kg) reduced oxidative stress and inflammation in the 5-fluorouracil-induced oral mucositis in hamsters.]]></description><subject>5-Fluorouracil</subject><subject>Anacardiaceae - chemistry</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antioxidants - pharmacology</subject><subject>Cricetinae</subject><subject>Dentistry</subject><subject>Inflammation</subject><subject>Male</subject><subject>Oral mucositis</subject><subject>Oxidative Stress</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves - chemistry</subject><subject>Spondias mombin</subject><subject>Stomatitis - drug therapy</subject><issn>0003-9969</issn><issn>1879-1506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUcuOFCEUJUbj9Iz-gsGdm2qBKihqOek4ajKJC3VNeFzSdKqgBXoyvffDpdKjcTkLcsK959zXQeg9JVtKqPh42Ops9ynr2YS0ZYSt8UGI4QXaUDlOHeVEvEQbQkjfTZOYrtB1KYf25ULQ1-iqp5NkgpAN-n0ba-hC9LNeFl1TPmMdXXs1pMfgGmJta3gI9YyTx_uzywnqXsc0B4vhseaWXjPfjym6oAte0mJCxDNojxvqiNdB8XKyqYQaShMdIYcFYl3DycH8Br3yei7w9glv0M-7Tz92X7r7b5-_7m7vOzswWTvOLQAXDjx1I3Pc2NF7IwfBiZmE9SP1o2PDZDQ4ybiRBpgbvZRDPwruXX-DPlzqHnP6dYJS1RKKhXnWEdKpKNYPgkkqJtao04Vqcyolg1fHNrPOZ0WJWk1QB_WfCWo1QV1MaNp3T21OZgH3T_n36o2wuxCgLfsQIKtiA0QLLmSwVbkUntHmD4R1op4</recordid><startdate>202003</startdate><enddate>202003</enddate><creator>Sousa Gomes, Mayra</creator><creator>Diógenes Alves Uchoa Lins, Ruthineia</creator><creator>Zucolotto Langassner, Silvana Maria</creator><creator>Dantas da Silveira, Éricka Janine</creator><creator>Gomes de Carvalho, Thais</creator><creator>Diniz de Sousa Lopes, Maria Luiza</creator><creator>de Souza Araújo, Lorena</creator><creator>Addison Carvalho Xavier de Medeiros, Caroline</creator><creator>Ferreira de Carvalho Leitão, Renata</creator><creator>Coelho Bernardo Guerra, Gerlane</creator><creator>Fernandes de Araújo Junior, Raimundo</creator><creator>Antunes de Araújo, Aurigena</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202003</creationdate><title>Anti-inflammatory and antioxidant activity of hydroethanolic extract of Spondias mombin leaf in an oral mucositis experimental model</title><author>Sousa Gomes, Mayra ; Diógenes Alves Uchoa Lins, Ruthineia ; Zucolotto Langassner, Silvana Maria ; Dantas da Silveira, Éricka Janine ; Gomes de Carvalho, Thais ; Diniz de Sousa Lopes, Maria Luiza ; de Souza Araújo, Lorena ; Addison Carvalho Xavier de Medeiros, Caroline ; Ferreira de Carvalho Leitão, Renata ; Coelho Bernardo Guerra, Gerlane ; Fernandes de Araújo Junior, Raimundo ; Antunes de Araújo, Aurigena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-55cee56def1d72d5bc7ffb84650b96cf71f7d249baed825b8be2d7f8843765fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>5-Fluorouracil</topic><topic>Anacardiaceae - chemistry</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antioxidants - pharmacology</topic><topic>Cricetinae</topic><topic>Dentistry</topic><topic>Inflammation</topic><topic>Male</topic><topic>Oral mucositis</topic><topic>Oxidative Stress</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Leaves - chemistry</topic><topic>Spondias mombin</topic><topic>Stomatitis - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sousa Gomes, Mayra</creatorcontrib><creatorcontrib>Diógenes Alves Uchoa Lins, Ruthineia</creatorcontrib><creatorcontrib>Zucolotto Langassner, Silvana Maria</creatorcontrib><creatorcontrib>Dantas da Silveira, Éricka Janine</creatorcontrib><creatorcontrib>Gomes de Carvalho, Thais</creatorcontrib><creatorcontrib>Diniz de Sousa Lopes, Maria Luiza</creatorcontrib><creatorcontrib>de Souza Araújo, Lorena</creatorcontrib><creatorcontrib>Addison Carvalho Xavier de Medeiros, Caroline</creatorcontrib><creatorcontrib>Ferreira de Carvalho Leitão, Renata</creatorcontrib><creatorcontrib>Coelho Bernardo Guerra, Gerlane</creatorcontrib><creatorcontrib>Fernandes de Araújo Junior, Raimundo</creatorcontrib><creatorcontrib>Antunes de Araújo, Aurigena</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of oral biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sousa Gomes, Mayra</au><au>Diógenes Alves Uchoa Lins, Ruthineia</au><au>Zucolotto Langassner, Silvana Maria</au><au>Dantas da Silveira, Éricka Janine</au><au>Gomes de Carvalho, Thais</au><au>Diniz de Sousa Lopes, Maria Luiza</au><au>de Souza Araújo, Lorena</au><au>Addison Carvalho Xavier de Medeiros, Caroline</au><au>Ferreira de Carvalho Leitão, Renata</au><au>Coelho Bernardo Guerra, Gerlane</au><au>Fernandes de Araújo Junior, Raimundo</au><au>Antunes de Araújo, Aurigena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-inflammatory and antioxidant activity of hydroethanolic extract of Spondias mombin leaf in an oral mucositis experimental model</atitle><jtitle>Archives of oral biology</jtitle><addtitle>Arch Oral Biol</addtitle><date>2020-03</date><risdate>2020</risdate><volume>111</volume><spage>104664</spage><epage>104664</epage><pages>104664-104664</pages><artnum>104664</artnum><issn>0003-9969</issn><eissn>1879-1506</eissn><abstract><![CDATA[•The animals treated with HESM at a dose of 200 mg/kg exhibited almost complete healing in all animals.•The HESM (200 mg/kg) group revealed a large amount of collagen fibers, which presented greater healing and granular tissue formation in the oral mucositis area.•MDA levels were lower in the HESM (200 mg/kg) group when compared to that observed in the 5FU/MT group (p < 0.001).•Inflammatory cytokine IL-1β was significantly lower in the HESM (200 mg/kg) group (p < 0.05) compared to 5FU/MT group.
Spondias mombin has been used in folk medicine to treat inflammation in the oral cavity. This study aimed to evaluate the antioxidant and anti-inflammatory activity of S. mombin extract in an oral mucositis experimental model.
Male hamsters were orally pre-treated with hydroethanolic extract of S. mombin leaves (HESM) (50, 100, or 200 mg/kg) for ten days. Cheek pouch samples were subjected to macroscopic, histopathological and immunohistochemical analysis (Cox-2, iNOS, NF-kB p50 NLS and MMP-2). IL-1β and TNF-α levels were analyzed by ELISA immunoassay, and Superoxide dismutase estimative (SOD), glutathione (GSH) and malondialdehyde (MDA) levels were submitted to spectroscopy analysis.
The group treated with HESM at a dose of 200 mg/kg showed the best healing effect, showing no evidence of ulceration in the macroscopic analysis (p < 0.05). Histopathological analysis showed re-epithelialization, discrete mononuclear inflammatory infiltrate and absence of hemorrhage and edema score of 1 (1-1) (p < 0.05), as well as a large amount of collagen fibers and a lower immunoexpression of Cox-2, iNOS, NF-kB p50 NLS and MMP-2. Decrease in SOD (p < 0.05), MDA (p<0.001), IL-1β (p < 0.05), and TNF-α levels (p < 0.001), with an increase in GSH (p < 0.01) levels.
HESM (200 mg/kg) reduced oxidative stress and inflammation in the 5-fluorouracil-induced oral mucositis in hamsters.]]></abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31982600</pmid><doi>10.1016/j.archoralbio.2020.104664</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives of oral biology, 2020-03, Vol.111, p.104664-104664, Article 104664 |
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| subjects | 5-Fluorouracil Anacardiaceae - chemistry Animals Anti-Inflammatory Agents - pharmacology Antioxidants - pharmacology Cricetinae Dentistry Inflammation Male Oral mucositis Oxidative Stress Plant Extracts - pharmacology Plant Leaves - chemistry Spondias mombin Stomatitis - drug therapy |
| title | Anti-inflammatory and antioxidant activity of hydroethanolic extract of Spondias mombin leaf in an oral mucositis experimental model |
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