Anti-inflammatory and antioxidant activity of hydroethanolic extract of Spondias mombin leaf in an oral mucositis experimental model

•The animals treated with HESM at a dose of 200 mg/kg exhibited almost complete healing in all animals.•The HESM (200 mg/kg) group revealed a large amount of collagen fibers, which presented greater healing and granular tissue formation in the oral mucositis area.•MDA levels were lower in the HESM (...

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Veröffentlicht in:	Archives of oral biology 2020-03, Vol.111, p.104664-104664, Article 104664
Hauptverfasser:	Sousa Gomes, Mayra, Diógenes Alves Uchoa Lins, Ruthineia, Zucolotto Langassner, Silvana Maria, Dantas da Silveira, Éricka Janine, Gomes de Carvalho, Thais, Diniz de Sousa Lopes, Maria Luiza, de Souza Araújo, Lorena, Addison Carvalho Xavier de Medeiros, Caroline, Ferreira de Carvalho Leitão, Renata, Coelho Bernardo Guerra, Gerlane, Fernandes de Araújo Junior, Raimundo, Antunes de Araújo, Aurigena
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Anacardiaceae - chemistry Animals Anti-Inflammatory Agents - pharmacology Antioxidants - pharmacology Cricetinae Dentistry Inflammation Male Oral mucositis Oxidative Stress Plant Extracts - pharmacology Plant Leaves - chemistry Spondias mombin Stomatitis - drug therapy
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Zusammenfassung:	•The animals treated with HESM at a dose of 200 mg/kg exhibited almost complete healing in all animals.•The HESM (200 mg/kg) group revealed a large amount of collagen fibers, which presented greater healing and granular tissue formation in the oral mucositis area.•MDA levels were lower in the HESM (200 mg/kg) group when compared to that observed in the 5FU/MT group (p
ISSN:	0003-9969 1879-1506
DOI:	10.1016/j.archoralbio.2020.104664