Cold fluids for induction of targeted temperature management: A sub-study of the TTH48 trial

Pre-intensive care unit (ICU) induction of targeted temperature management (TTM) with cold intravenous (i.v.) fluids does not appear to improve outcomes after in out-of-hospital cardiac arrest (OHCA). We hypothesized that this may be due to ineffective cooling and side effects. A post hoc analysis o...

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Veröffentlicht in:Resuscitation 2020-03, Vol.148, p.90-97
Hauptverfasser: Holm, Aki, Kirkegaard, Hans, Taccone, Fabio, Søreide, Eldar, Grejs, Anders, Duez, Christophe, Jeppesen, Anni, Toome, Valdo, Hassager C, Christian, Rasmussen, Bodil S, Laitio, Timo, Storm, Christian, Hästbacka, Johanna, Skrifvars, Markus B
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Sprache:eng
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Zusammenfassung:Pre-intensive care unit (ICU) induction of targeted temperature management (TTM) with cold intravenous (i.v.) fluids does not appear to improve outcomes after in out-of-hospital cardiac arrest (OHCA). We hypothesized that this may be due to ineffective cooling and side effects. A post hoc analysis of a sub-group of patients (n = 352) in the TTH48 trial (NCT01689077) who received or did not receive pre-ICU cooling using cold i.v. fluids. Data collection included patient characteristics, cardiac arrest factors, cooling methods, side effects and continuous core temperature measurements. The primary endpoint was the time to target temperature (TTT,
ISSN:0300-9572
1873-1570
DOI:10.1016/j.resuscitation.2019.11.031