Effects of CYP2C192 polymorphisms on the efficacy and safety of phenazepam in patients with anxiety disorder and comorbid alcohol use disorder

Phenazepam therapy can often be ineffective and some patients develop dose-related adverse drug reactions. The purpose of this research was to study the effect of the (681G>A, rs4244285) in patients with anxiety disorders and alcohol dependence taking phenazepam therapy. Patients (175 males, average age: 37.16 ± 7.84 years) received phenazepam in tablet form for 5 days. Genotyping was performed by real-time polymerase chain reaction. The statistically significant differences in the UKU Side-Effect Rating Scale scores on the fifth day of therapy: ( ) 2.00 [1.00; 2.00), ( ) 7.00 (7.00; 7.00), ( ) 9.00 (8.00; 9.00), p