Maternal exposure to air pollution during pregnancy and cortisol level in cord blood

Exposure to air pollution has been associated with disorders of the endocrine system and hypothalamic-pituitary-adrenal (HPA) axis; however, the available evidence on these associations is still scarce. This study aimed to investigate, for the first time, the association of exposure to PM1, PM2.5, and PM10, as well as traffic indicators (distance to major roads and total street length in different buffers around maternal residential address) during pregnancy with cortisol level in cord blood samples. This cross-sectional study was carried out based on 150 mother-newborn pairs in Sabzevar, Iran (2018). Land use regression models were applied to estimate air pollution exposure during the entire pregnancy at maternal residential addresses. Multiple linear regression models were applied to estimate the association of exposure to air pollution during pregnancy and cord blood cortisol levels, controlled for relevant covariates. There was a significant positive association between exposure to PM2.5 and PM10 and cortisol levels in cord blood (β = 2.55, 95% confidence intervals (CI) = 0.57, 4.52, P-value = 0.01, and β = 3.09, 95% CI: 1.28, 4.90, P-value