Virus-Induced Interferon Regulates the Urea Cycle
Integrating transcriptomic, proteomic, and metabolomic data, Lercher et al. show in a mouse model of LCMV infection that type I interferon alters the expression and function of key enzymes of the urea cycle in hepatocytes. This results in altered systemic metabolism, attenuating antiviral T cell res...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 2019-12, Vol.51 (6), p.975-977 |
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| container_title | Immunity (Cambridge, Mass.) |
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| creator | Nishio, Akira Rehermann, Barbara |
| description | Integrating transcriptomic, proteomic, and metabolomic data, Lercher et al. show in a mouse model of LCMV infection that type I interferon alters the expression and function of key enzymes of the urea cycle in hepatocytes. This results in altered systemic metabolism, attenuating antiviral T cell responses and ameliorating liver injury.
Integrating transcriptomic, proteomic, and metabolomic data, Lercher et al. show in a mouse model of LCMV infection that type I interferon alters the expression and function of key enzymes of the urea cycle in hepatocytes. This results in altered systemic metabolism, attenuating antiviral T cell responses and ameliorating liver injury. |
| doi_str_mv | 10.1016/j.immuni.2019.11.012 |
| format | Article |
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Integrating transcriptomic, proteomic, and metabolomic data, Lercher et al. show in a mouse model of LCMV infection that type I interferon alters the expression and function of key enzymes of the urea cycle in hepatocytes. This results in altered systemic metabolism, attenuating antiviral T cell responses and ameliorating liver injury.</description><identifier>ISSN: 1074-7613</identifier><identifier>EISSN: 1097-4180</identifier><identifier>DOI: 10.1016/j.immuni.2019.11.012</identifier><identifier>PMID: 31951542</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amino acids ; Animals ; Antiviral Agents ; Bioinformatics ; Cytokines ; Enzymes ; Hepatitis ; Hepatocytes ; Infections ; Interferon ; Interferon Type I ; Lipids ; Liver ; Liver cancer ; Liver cirrhosis ; Liver diseases ; Lymphocytes ; Lymphocytes T ; Lymphocytic choriomeningitis virus ; Metabolism ; Metabolites ; Metabolomics ; Mice ; Proteomics ; T-Lymphocytes ; Urea ; Viruses</subject><ispartof>Immunity (Cambridge, Mass.), 2019-12, Vol.51 (6), p.975-977</ispartof><rights>2019</rights><rights>Published by Elsevier Inc.</rights><rights>Copyright Elsevier Limited Dec 17, 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-dba454bf9dfc4d8050997632ac3f2ab7df49e41778dfb433b944f628cae2519e3</citedby><cites>FETCH-LOGICAL-c436t-dba454bf9dfc4d8050997632ac3f2ab7df49e41778dfb433b944f628cae2519e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.immuni.2019.11.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31951542$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nishio, Akira</creatorcontrib><creatorcontrib>Rehermann, Barbara</creatorcontrib><title>Virus-Induced Interferon Regulates the Urea Cycle</title><title>Immunity (Cambridge, Mass.)</title><addtitle>Immunity</addtitle><description>Integrating transcriptomic, proteomic, and metabolomic data, Lercher et al. show in a mouse model of LCMV infection that type I interferon alters the expression and function of key enzymes of the urea cycle in hepatocytes. This results in altered systemic metabolism, attenuating antiviral T cell responses and ameliorating liver injury.
Integrating transcriptomic, proteomic, and metabolomic data, Lercher et al. show in a mouse model of LCMV infection that type I interferon alters the expression and function of key enzymes of the urea cycle in hepatocytes. This results in altered systemic metabolism, attenuating antiviral T cell responses and ameliorating liver injury.</description><subject>Amino acids</subject><subject>Animals</subject><subject>Antiviral Agents</subject><subject>Bioinformatics</subject><subject>Cytokines</subject><subject>Enzymes</subject><subject>Hepatitis</subject><subject>Hepatocytes</subject><subject>Infections</subject><subject>Interferon</subject><subject>Interferon Type I</subject><subject>Lipids</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Lymphocytic choriomeningitis virus</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Metabolomics</subject><subject>Mice</subject><subject>Proteomics</subject><subject>T-Lymphocytes</subject><subject>Urea</subject><subject>Viruses</subject><issn>1074-7613</issn><issn>1097-4180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LJDEQhoOsqKv-g0Ua9uKl21SS7nQuC8ug7oAgiHoN6aTiZugPTboF_70ZRj3sYU9Vh-d9q3gI-QG0AgrNxaYKw7CMoWIUVAVQUWB75AiokqWAln7b7lKUsgF-SL6ntKEURK3oATnkoGqoBTsi8Bjiksr16BaLrliPM0aPcRqLO3xaejNjKua_WDxENMXqzfZ4Qva96ROefsxj8nB1eb_6U97cXq9Xv29KK3gzl64zohadV85b4VpaU6Vkw5mx3DPTSeeFQgFSts53gvNOCeEb1lqDrAaF_Jic73qf4_SyYJr1EJLFvjcjTkvSjAtoWN1Cm9Gf_6CbaYlj_i5TTLaKUckzJXaUjVNKEb1-jmEw8U0D1VuleqN3SvVWqQbQWWmOnX2UL92A7iv06TADv3YAZhuvAaNONuCYdYaIdtZuCv-_8A79KYeD</recordid><startdate>20191217</startdate><enddate>20191217</enddate><creator>Nishio, Akira</creator><creator>Rehermann, Barbara</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20191217</creationdate><title>Virus-Induced Interferon Regulates the Urea Cycle</title><author>Nishio, Akira ; Rehermann, Barbara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-dba454bf9dfc4d8050997632ac3f2ab7df49e41778dfb433b944f628cae2519e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Amino acids</topic><topic>Animals</topic><topic>Antiviral Agents</topic><topic>Bioinformatics</topic><topic>Cytokines</topic><topic>Enzymes</topic><topic>Hepatitis</topic><topic>Hepatocytes</topic><topic>Infections</topic><topic>Interferon</topic><topic>Interferon Type I</topic><topic>Lipids</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Liver cirrhosis</topic><topic>Liver diseases</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Lymphocytic choriomeningitis virus</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Metabolomics</topic><topic>Mice</topic><topic>Proteomics</topic><topic>T-Lymphocytes</topic><topic>Urea</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishio, Akira</creatorcontrib><creatorcontrib>Rehermann, Barbara</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunity (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishio, Akira</au><au>Rehermann, Barbara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Virus-Induced Interferon Regulates the Urea Cycle</atitle><jtitle>Immunity (Cambridge, Mass.)</jtitle><addtitle>Immunity</addtitle><date>2019-12-17</date><risdate>2019</risdate><volume>51</volume><issue>6</issue><spage>975</spage><epage>977</epage><pages>975-977</pages><issn>1074-7613</issn><eissn>1097-4180</eissn><abstract>Integrating transcriptomic, proteomic, and metabolomic data, Lercher et al. show in a mouse model of LCMV infection that type I interferon alters the expression and function of key enzymes of the urea cycle in hepatocytes. This results in altered systemic metabolism, attenuating antiviral T cell responses and ameliorating liver injury.
Integrating transcriptomic, proteomic, and metabolomic data, Lercher et al. show in a mouse model of LCMV infection that type I interferon alters the expression and function of key enzymes of the urea cycle in hepatocytes. This results in altered systemic metabolism, attenuating antiviral T cell responses and ameliorating liver injury.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31951542</pmid><doi>10.1016/j.immuni.2019.11.012</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Cell Press Free Archives; Access via ScienceDirect (Elsevier); EZB Electronic Journals Library |
| subjects | Amino acids Animals Antiviral Agents Bioinformatics Cytokines Enzymes Hepatitis Hepatocytes Infections Interferon Interferon Type I Lipids Liver Liver cancer Liver cirrhosis Liver diseases Lymphocytes Lymphocytes T Lymphocytic choriomeningitis virus Metabolism Metabolites Metabolomics Mice Proteomics T-Lymphocytes Urea Viruses |
| title | Virus-Induced Interferon Regulates the Urea Cycle |
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