Virus-Induced Interferon Regulates the Urea Cycle

Integrating transcriptomic, proteomic, and metabolomic data, Lercher et al. show in a mouse model of LCMV infection that type I interferon alters the expression and function of key enzymes of the urea cycle in hepatocytes. This results in altered systemic metabolism, attenuating antiviral T cell res...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2019-12, Vol.51 (6), p.975-977
Hauptverfasser:	Nishio, Akira, Rehermann, Barbara
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Antiviral Agents Bioinformatics Cytokines Enzymes Hepatitis Hepatocytes Infections Interferon Interferon Type I Lipids Liver Liver cancer Liver cirrhosis Liver diseases Lymphocytes Lymphocytes T Lymphocytic choriomeningitis virus Metabolism Metabolites Metabolomics Mice Proteomics T-Lymphocytes Urea Viruses
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Beschreibung
Zusammenfassung:	Integrating transcriptomic, proteomic, and metabolomic data, Lercher et al. show in a mouse model of LCMV infection that type I interferon alters the expression and function of key enzymes of the urea cycle in hepatocytes. This results in altered systemic metabolism, attenuating antiviral T cell responses and ameliorating liver injury. Integrating transcriptomic, proteomic, and metabolomic data, Lercher et al. show in a mouse model of LCMV infection that type I interferon alters the expression and function of key enzymes of the urea cycle in hepatocytes. This results in altered systemic metabolism, attenuating antiviral T cell responses and ameliorating liver injury.
ISSN:	1074-7613 1097-4180
DOI:	10.1016/j.immuni.2019.11.012