Disconnect between effects of mepolizumab on severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps

An ACQ-6 score of less than 0.75 denotes good control and more than 1.5 denotes poor control. [...]the ACQ score is a strong predictor of future exacerbation risk.7 The mean number of asthma exacerbations requiring oral corticosteroids (OCSs) in the ensuing 12 months fell from 4 before treatment to 1 after treatment. [...]we would like to emphasize that this was a real-world retrospective case series based on case note review and as such may not reflect results from prospective RCTs or prospective real-life follow-up trials. [...]standard doses of mepolizumab significantly improved asthma control but not NP in our cohort of patients with uncontrolled SEA with concomitant CRSwNP.