Phenotypic characterization of macrophages in the BMB sample of human acute leukemia

Macrophages within tissues display a strong plastic ability in respond to environmental cues in both physiologic influences and disease. However, the macrophage phenotype and its distribution in the bone marrow biopsies (BMB) samples of human acute leukemia (AL) remain poorly understood. In this stu...

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Veröffentlicht in:	Annals of hematology 2020-03, Vol.99 (3), p.539-547
Hauptverfasser:	Song, Jian-Xin, Wen, Yan, Li, Rui-Wei, Dong, Ting, Tang, Yi-Fei, Zhang, Juan-Juan, Sa, Ya-Lian
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adolescent Adult Aged Antigens, Differentiation - metabolism Biopsy Bone Marrow - metabolism Bone Marrow - pathology Female Hematology Humans Leukemia Leukemia - metabolism Leukemia - pathology Macrophages - metabolism Macrophages - pathology Male Medicine Medicine & Public Health Middle Aged Neoplasm Proteins - metabolism Oncology Original Article
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Zusammenfassung:	Macrophages within tissues display a strong plastic ability in respond to environmental cues in both physiologic influences and disease. However, the macrophage phenotype and its distribution in the bone marrow biopsies (BMB) samples of human acute leukemia (AL) remain poorly understood. In this study, 97 BMB samples of patients with acute leukemia and 30 iron-deficiency anemias (IDA) as control group were evaluated with immunohistochemistry. In comparison with controls, the counts of CD68 + , CD163 + , and CD206 + macrophages were remarkably increased in BMB samples of acute leukemia ( P
ISSN:	0939-5555 1432-0584
DOI:	10.1007/s00277-020-03912-y