Amniotic fluid‐derived mesenchymal stem cell products combined with microneedling for acne scars: A split‐face clinical, histological, and histometric study
Background Postacne scars are still a challenge in its management. Microneedling is a popular minimally invasive technique in treatment of such scars. However, the addition of topical stem cell products after microneedling is considered a new treatment regimen for these scars. Objective To compare e...
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| Veröffentlicht in: | Journal of cosmetic dermatology 2019-10, Vol.18 (5), p.1300-1306 |
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| container_title | Journal of cosmetic dermatology |
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| creator | El-Domyati, Moetaz Moftah, Noha H. Nasif, Ghada A. Ragaie, Maha H. Ibrahim, Michel R. Ameen, Sameh W. |
| description | Background
Postacne scars are still a challenge in its management. Microneedling is a popular minimally invasive technique in treatment of such scars. However, the addition of topical stem cell products after microneedling is considered a new treatment regimen for these scars.
Objective
To compare efficacy of amniotic fluid‐derived mesenchymal stem cell‐conditioned media (AF‐MSC‐CM) and microneedling vs microneedling alone in management of atrophic acne scars.
Methods
Ten cases with atrophic postacne scars received five sessions of microneedling, with 2‐week interval on both sides of the face. Then, AF‐MSC‐CM was topically applied to right side of the face after microneedling. Clinical examination with histopathological and computerized histometric analysis was done 1 month after the sessions.
Results
There was significant increase in the improvement percentage of acne scars on right side (dermaroller and AF‐MSC‐CM) vs left side of face (dermaroller; P |
| doi_str_mv | 10.1111/jocd.13039 |
| format | Article |
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Postacne scars are still a challenge in its management. Microneedling is a popular minimally invasive technique in treatment of such scars. However, the addition of topical stem cell products after microneedling is considered a new treatment regimen for these scars.
Objective
To compare efficacy of amniotic fluid‐derived mesenchymal stem cell‐conditioned media (AF‐MSC‐CM) and microneedling vs microneedling alone in management of atrophic acne scars.
Methods
Ten cases with atrophic postacne scars received five sessions of microneedling, with 2‐week interval on both sides of the face. Then, AF‐MSC‐CM was topically applied to right side of the face after microneedling. Clinical examination with histopathological and computerized histometric analysis was done 1 month after the sessions.
Results
There was significant increase in the improvement percentage of acne scars on right side (dermaroller and AF‐MSC‐CM) vs left side of face (dermaroller; P < 0.001). Histologically, improvement of character of collagen and elastic fibers was noticed, especially on right side. Meanwhile, significant increase in epidermal thickness on both sides of face was detected.
Conclusion
Amniotic fluid‐derived mesenchymal stem cell‐conditioned media combined with microneedling is more effective in management of atrophic postacne scars than microneedling alone.</description><identifier>ISSN: 1473-2130</identifier><identifier>EISSN: 1473-2165</identifier><identifier>DOI: 10.1111/jocd.13039</identifier><identifier>PMID: 31173459</identifier><language>eng</language><publisher>England</publisher><subject>acne scars ; amniotic fluid stem cells products ; dermaroller ; growth factors ; microneedling</subject><ispartof>Journal of cosmetic dermatology, 2019-10, Vol.18 (5), p.1300-1306</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3299-6714ffc9c3e074e7f00d7bf41c509bb8ab1aea5b5d2e2bd48cf6bb18ecd986d43</citedby><cites>FETCH-LOGICAL-c3299-6714ffc9c3e074e7f00d7bf41c509bb8ab1aea5b5d2e2bd48cf6bb18ecd986d43</cites><orcidid>0000-0002-9579-6149 ; 0000-0002-0444-2311 ; 0000-0002-8921-2442</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjocd.13039$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjocd.13039$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31173459$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-Domyati, Moetaz</creatorcontrib><creatorcontrib>Moftah, Noha H.</creatorcontrib><creatorcontrib>Nasif, Ghada A.</creatorcontrib><creatorcontrib>Ragaie, Maha H.</creatorcontrib><creatorcontrib>Ibrahim, Michel R.</creatorcontrib><creatorcontrib>Ameen, Sameh W.</creatorcontrib><title>Amniotic fluid‐derived mesenchymal stem cell products combined with microneedling for acne scars: A split‐face clinical, histological, and histometric study</title><title>Journal of cosmetic dermatology</title><addtitle>J Cosmet Dermatol</addtitle><description>Background
Postacne scars are still a challenge in its management. Microneedling is a popular minimally invasive technique in treatment of such scars. However, the addition of topical stem cell products after microneedling is considered a new treatment regimen for these scars.
Objective
To compare efficacy of amniotic fluid‐derived mesenchymal stem cell‐conditioned media (AF‐MSC‐CM) and microneedling vs microneedling alone in management of atrophic acne scars.
Methods
Ten cases with atrophic postacne scars received five sessions of microneedling, with 2‐week interval on both sides of the face. Then, AF‐MSC‐CM was topically applied to right side of the face after microneedling. Clinical examination with histopathological and computerized histometric analysis was done 1 month after the sessions.
Results
There was significant increase in the improvement percentage of acne scars on right side (dermaroller and AF‐MSC‐CM) vs left side of face (dermaroller; P < 0.001). Histologically, improvement of character of collagen and elastic fibers was noticed, especially on right side. Meanwhile, significant increase in epidermal thickness on both sides of face was detected.
Conclusion
Amniotic fluid‐derived mesenchymal stem cell‐conditioned media combined with microneedling is more effective in management of atrophic postacne scars than microneedling alone.</description><subject>acne scars</subject><subject>amniotic fluid stem cells products</subject><subject>dermaroller</subject><subject>growth factors</subject><subject>microneedling</subject><issn>1473-2130</issn><issn>1473-2165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kU1uFDEQRi1EREJgwwGQlwgxwW53T4_ZjYa_oEjZwLpll8sZR3Z7sN2JZscROAJn4yTx0EmWeFN26enJnz5CXnF2xut5fx3BnHHBhHxCTnjbi0XDl93Tx7tgx-R5zteM8V7y7hk5Fpz3ou3kCfmzDqOLxQG1fnLm76_fBpO7QUMDZhxhuw_K01wwUEDv6S5FM0HJFGLQbqzcrStbGhykOCIa78YramOiCkakGVTKH-ia5p13pcqtAqRQIQfKv6Nbl0v08Wp-qdHMm4Al1R_lMpn9C3Jklc_48n6ekh-fP33ffF1cXH4536wvFiAaKRfLnrfWggSBrG-xt4yZXtuWQ8ek1iuluULV6c402GjTrsAuteYrBCNXS9OKU_Jm9taEPyfMZQguHyKrEeOUh0a0jLVSSF7RtzNaM-ec0A675IJK-4Gz4dDIcGhk-NdIhV_feycd0DyiDxVUgM_ArfO4_49q-Ha5-ThL7wCAgZzD</recordid><startdate>201910</startdate><enddate>201910</enddate><creator>El-Domyati, Moetaz</creator><creator>Moftah, Noha H.</creator><creator>Nasif, Ghada A.</creator><creator>Ragaie, Maha H.</creator><creator>Ibrahim, Michel R.</creator><creator>Ameen, Sameh W.</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9579-6149</orcidid><orcidid>https://orcid.org/0000-0002-0444-2311</orcidid><orcidid>https://orcid.org/0000-0002-8921-2442</orcidid></search><sort><creationdate>201910</creationdate><title>Amniotic fluid‐derived mesenchymal stem cell products combined with microneedling for acne scars: A split‐face clinical, histological, and histometric study</title><author>El-Domyati, Moetaz ; Moftah, Noha H. ; Nasif, Ghada A. ; Ragaie, Maha H. ; Ibrahim, Michel R. ; Ameen, Sameh W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3299-6714ffc9c3e074e7f00d7bf41c509bb8ab1aea5b5d2e2bd48cf6bb18ecd986d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>acne scars</topic><topic>amniotic fluid stem cells products</topic><topic>dermaroller</topic><topic>growth factors</topic><topic>microneedling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Domyati, Moetaz</creatorcontrib><creatorcontrib>Moftah, Noha H.</creatorcontrib><creatorcontrib>Nasif, Ghada A.</creatorcontrib><creatorcontrib>Ragaie, Maha H.</creatorcontrib><creatorcontrib>Ibrahim, Michel R.</creatorcontrib><creatorcontrib>Ameen, Sameh W.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cosmetic dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Domyati, Moetaz</au><au>Moftah, Noha H.</au><au>Nasif, Ghada A.</au><au>Ragaie, Maha H.</au><au>Ibrahim, Michel R.</au><au>Ameen, Sameh W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amniotic fluid‐derived mesenchymal stem cell products combined with microneedling for acne scars: A split‐face clinical, histological, and histometric study</atitle><jtitle>Journal of cosmetic dermatology</jtitle><addtitle>J Cosmet Dermatol</addtitle><date>2019-10</date><risdate>2019</risdate><volume>18</volume><issue>5</issue><spage>1300</spage><epage>1306</epage><pages>1300-1306</pages><issn>1473-2130</issn><eissn>1473-2165</eissn><abstract>Background
Postacne scars are still a challenge in its management. Microneedling is a popular minimally invasive technique in treatment of such scars. However, the addition of topical stem cell products after microneedling is considered a new treatment regimen for these scars.
Objective
To compare efficacy of amniotic fluid‐derived mesenchymal stem cell‐conditioned media (AF‐MSC‐CM) and microneedling vs microneedling alone in management of atrophic acne scars.
Methods
Ten cases with atrophic postacne scars received five sessions of microneedling, with 2‐week interval on both sides of the face. Then, AF‐MSC‐CM was topically applied to right side of the face after microneedling. Clinical examination with histopathological and computerized histometric analysis was done 1 month after the sessions.
Results
There was significant increase in the improvement percentage of acne scars on right side (dermaroller and AF‐MSC‐CM) vs left side of face (dermaroller; P < 0.001). Histologically, improvement of character of collagen and elastic fibers was noticed, especially on right side. Meanwhile, significant increase in epidermal thickness on both sides of face was detected.
Conclusion
Amniotic fluid‐derived mesenchymal stem cell‐conditioned media combined with microneedling is more effective in management of atrophic postacne scars than microneedling alone.</abstract><cop>England</cop><pmid>31173459</pmid><doi>10.1111/jocd.13039</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9579-6149</orcidid><orcidid>https://orcid.org/0000-0002-0444-2311</orcidid><orcidid>https://orcid.org/0000-0002-8921-2442</orcidid></addata></record> |
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| ispartof | Journal of cosmetic dermatology, 2019-10, Vol.18 (5), p.1300-1306 |
| issn | 1473-2130 1473-2165 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | acne scars amniotic fluid stem cells products dermaroller growth factors microneedling |
| title | Amniotic fluid‐derived mesenchymal stem cell products combined with microneedling for acne scars: A split‐face clinical, histological, and histometric study |
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