Amniotic fluid‐derived mesenchymal stem cell products combined with microneedling for acne scars: A split‐face clinical, histological, and histometric study

Background Postacne scars are still a challenge in its management. Microneedling is a popular minimally invasive technique in treatment of such scars. However, the addition of topical stem cell products after microneedling is considered a new treatment regimen for these scars. Objective To compare efficacy of amniotic fluid‐derived mesenchymal stem cell‐conditioned media (AF‐MSC‐CM) and microneedling vs microneedling alone in management of atrophic acne scars. Methods Ten cases with atrophic postacne scars received five sessions of microneedling, with 2‐week interval on both sides of the face. Then, AF‐MSC‐CM was topically applied to right side of the face after microneedling. Clinical examination with histopathological and computerized histometric analysis was done 1 month after the sessions. Results There was significant increase in the improvement percentage of acne scars on right side (dermaroller and AF‐MSC‐CM) vs left side of face (dermaroller; P