Cancer Genome Evolutionary Trajectories in Metastasis

Metastatic cancer is a major cause of death and remains largely incurable. A better understanding of metastasis is therefore desperately needed to improve prognosis for late-stage disease. Here we survey the landscape of studies exploring the genomics of metastatic cancer. We consider evidence for g...

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Veröffentlicht in:	Cancer cell 2020-01, Vol.37 (1), p.8-19
Hauptverfasser:	Birkbak, Nicolai J., McGranahan, Nicholas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cancer drivers cancer evolution cancer genomics clonal heterogeneity Disease Progression evolutionary trajectories Genome, Human Genomics Humans immune escape Immune System metastasis metastatic drivers Mice monoclonal dissemination Mutation Neoplasm Metastasis Neoplasms - diagnosis Neoplasms - genetics Neoplasms - pathology polyclonal dissemination Prognosis
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Beschreibung
Zusammenfassung:	Metastatic cancer is a major cause of death and remains largely incurable. A better understanding of metastasis is therefore desperately needed to improve prognosis for late-stage disease. Here we survey the landscape of studies exploring the genomics of metastatic cancer. We consider evidence for genomic drivers of metastasis and explore studies investigating modes of metastatic spread. Metastatic cancer is a major cause of death and remains largely incurable. A better understanding of metastasis is therefore desperately needed to improve prognosis for late-stage disease. Here, we survey the landscape of studies exploring the genomics of metastatic cancer. We consider evidence for genomic drivers of metastasis and explore studies investigating modes of metastatic spread.
ISSN:	1535-6108 1878-3686
DOI:	10.1016/j.ccell.2019.12.004