Copper-catalyzed asymmetric silyl addition to alkenyl-substituted N-heteroarenes

Copper-catalyzed asymmetric silyl addition to alkenyl-substituted N-heteroarenes

Asymmetric conjugate addition of PhMe2SiBPin to a wide range of N-heteroaryl alkenes proceeded in the presence of a copper catalyst coordinated with an easily accessible chiral phosphoramidite ligand to afford useful β-silyl N-heteroarenes in high yields (up to 96%) and excellent enantioselectivitie...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2020-02, Vol.56 (11), p.1693-1696
Hauptverfasser: Zeng, Ya-Li, Chen, Bo, Wang, Ya-Ting, He, Cheng-Yu, Mu, Zi-Yuan, Du, Ji-Yuan, He, Long, Chu, Wen-Dao, Liu, Quan-Zhong
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes
Asymmetry
Copper
Crystal structure
Crystallography
NMR
Nuclear magnetic resonance
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Zusammenfassung:Asymmetric conjugate addition of PhMe2SiBPin to a wide range of N-heteroaryl alkenes proceeded in the presence of a copper catalyst coordinated with an easily accessible chiral phosphoramidite ligand to afford useful β-silyl N-heteroarenes in high yields (up to 96%) and excellent enantioselectivities (up to 97% ee).
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc08910a