Clinical features and prognosis of late-onset neuromyelitis optica spectrum disorders in a Latin American cohort

Background We aimed to assess the clinical, paraclinical, imaging and prognostic features of patients with late-onset neuromyelitis optica spectrum disorder (LO-NMOSD; ≥ 50 years at disease onset) LO-NMOSD, compared with early onset-NMOSD (EO-NMOSD, ≤ 49 years at disease onset), in Latin American (L...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of neurology 2020-05, Vol.267 (5), p.1260-1268
Hauptverfasser: Carnero Contentti, Edgar, Daccach Marques, Vanessa, Soto de Castillo, Ibis, Tkachuk, Verónica, Ariel, Bustos, Castillo, Maria C., Cristiano, Edgardo, Diégues Serva, Gabriel Braga, dos Santos, Antonio Carlos, Finkelsteyn, Ana Mariel, López, Pablo A., Patrucco, Liliana, Molina, Omaira, Pettinicchi, Juan Pablo, Toneguzzo, Vanesa, Caride, Alejandro, Rojas, Juan Ignacio
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Background We aimed to assess the clinical, paraclinical, imaging and prognostic features of patients with late-onset neuromyelitis optica spectrum disorder (LO-NMOSD; ≥ 50 years at disease onset) LO-NMOSD, compared with early onset-NMOSD (EO-NMOSD, ≤ 49 years at disease onset), in Latin American (LATAM). Methods We retrospectively reviewed the medical records of patients with NMOSD, as defined using the 2015 validated diagnostic criteria. We included patients from Argentina, Brazil and Venezuela. They were divided into: LO-NMOSD and EO-NMOSD and comparison among the groups were performed. Results Among these 140 NMOSD patients, 24 (17.1%) were LO-NMOSD; 64% were positive for aquaporin-4 antibodies; and 41.5% of this population cohort was non-Caucasian. Severe disability [expanded disability status scale (EDSS) ≥ 6] at the last follow-up and presence of comorbidities were significantly associated with LO-NMOSD, compared with EO-NMOSD. LO-NMOSD patients had a shorter median time to EDSS ≥ 4 than EO-NMOSD patients (46 vs. 60 months; log-rank test p  = 0.0006). Furthermore, we observed a positive correlation between age at onset and EDSS score at the last follow-up (Spearman r  = 0.34, p  
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-020-09699-2