Quantifying steatosis in the liver and pancreas with MRI in patient with chronic liver disease
To compare pancreatic and hepatic steatosis quantified by proton density fat fraction (PDFF) on magnetic resonance imaging (MRI) in patients with chronic liver disease. This cross-sectional study included 46 adult patients who underwent liver biopsy for chronic viral hepatitis (n=19) or other chroni...
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| Veröffentlicht in: | Radiologia 2020-05, Vol.62 (3), p.222-228 |
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| creator | Vieira, J Amorim, J Martí-Bonmatí, L Alberich-Bayarri, Á França, M |
| description | To compare pancreatic and hepatic steatosis quantified by proton density fat fraction (PDFF) on magnetic resonance imaging (MRI) in patients with chronic liver disease.
This cross-sectional study included 46 adult patients who underwent liver biopsy for chronic viral hepatitis (n=19) or other chronic non-alcoholic liver diseases (NALD) (n=27). Liver biopsy was used as the gold standard for diagnosing and grading hepatic steatosis. All patients underwent clinical evaluation and MRI with a multi-echo chemical shift-encoded (MECSE) gradient-echo sequence for liver and pancreas PDFF quantification. We used Spearman's correlation coefficient to determine the degree of association between hepatic PDFF and steatosis grade, and between pancreatic PDFF and steatosis grade and hepatic PDFF. To compare the chronic viral hepatitis group and the NALD group, we used t-tests for continuous or ordinal variables and chi-square tests for categorical variables.
Hepatic PDFF measurements correlated with steatosis grades (R
=0.875, p |
| doi_str_mv | 10.1016/j.rx.2019.11.007 |
| format | Article |
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This cross-sectional study included 46 adult patients who underwent liver biopsy for chronic viral hepatitis (n=19) or other chronic non-alcoholic liver diseases (NALD) (n=27). Liver biopsy was used as the gold standard for diagnosing and grading hepatic steatosis. All patients underwent clinical evaluation and MRI with a multi-echo chemical shift-encoded (MECSE) gradient-echo sequence for liver and pancreas PDFF quantification. We used Spearman's correlation coefficient to determine the degree of association between hepatic PDFF and steatosis grade, and between pancreatic PDFF and steatosis grade and hepatic PDFF. To compare the chronic viral hepatitis group and the NALD group, we used t-tests for continuous or ordinal variables and chi-square tests for categorical variables.
Hepatic PDFF measurements correlated with steatosis grades (R
=0.875, p<0.001). Pancreatic PDFF correlated with hepatic steatosis grades (R
=0.573, p<0.001) and hepatic PDFF measurements (R
=0.536, p<0.001). In the subgroup of patients with chronic NALD, the correlations remained significant between pancreatic PDFF and hepatic PDFF (R
=0.632, p<0.001) and between pancreatic PDFF and liver steatosis (R
=0.608, p<0.001); however, in the subgroup of patients with viral hepatitis these correlations were no longer significant.
Pancreatic fat deposition correlates with hepatic steatosis in patients with chronic NALD, but not in those with chronic viral hepatitis.</description><identifier>EISSN: 1578-178X</identifier><identifier>EISSN: 2173-5107</identifier><identifier>DOI: 10.1016/j.rx.2019.11.007</identifier><identifier>PMID: 31932016</identifier><language>eng ; spa</language><publisher>Spain</publisher><subject>Adult ; Aged ; Biopsy - standards ; Chi-Square Distribution ; Chronic Disease ; Cross-Sectional Studies ; Fatty Liver - diagnostic imaging ; Fatty Liver - pathology ; Female ; Hepatitis, Viral, Human - diagnostic imaging ; Humans ; Lipomatosis - diagnostic imaging ; Lipomatosis - pathology ; Liver - pathology ; Liver Diseases - complications ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease - diagnostic imaging ; Pancreatic Diseases - diagnostic imaging ; Pancreatic Diseases - pathology ; Statistics, Nonparametric ; Young Adult</subject><ispartof>Radiologia, 2020-05, Vol.62 (3), p.222-228</ispartof><rights>Copyright © 2019 SERAM. Publicado por Elsevier España, S.L.U. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31932016$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vieira, J</creatorcontrib><creatorcontrib>Amorim, J</creatorcontrib><creatorcontrib>Martí-Bonmatí, L</creatorcontrib><creatorcontrib>Alberich-Bayarri, Á</creatorcontrib><creatorcontrib>França, M</creatorcontrib><title>Quantifying steatosis in the liver and pancreas with MRI in patient with chronic liver disease</title><title>Radiologia</title><addtitle>Radiologia</addtitle><description>To compare pancreatic and hepatic steatosis quantified by proton density fat fraction (PDFF) on magnetic resonance imaging (MRI) in patients with chronic liver disease.
This cross-sectional study included 46 adult patients who underwent liver biopsy for chronic viral hepatitis (n=19) or other chronic non-alcoholic liver diseases (NALD) (n=27). Liver biopsy was used as the gold standard for diagnosing and grading hepatic steatosis. All patients underwent clinical evaluation and MRI with a multi-echo chemical shift-encoded (MECSE) gradient-echo sequence for liver and pancreas PDFF quantification. We used Spearman's correlation coefficient to determine the degree of association between hepatic PDFF and steatosis grade, and between pancreatic PDFF and steatosis grade and hepatic PDFF. To compare the chronic viral hepatitis group and the NALD group, we used t-tests for continuous or ordinal variables and chi-square tests for categorical variables.
Hepatic PDFF measurements correlated with steatosis grades (R
=0.875, p<0.001). Pancreatic PDFF correlated with hepatic steatosis grades (R
=0.573, p<0.001) and hepatic PDFF measurements (R
=0.536, p<0.001). In the subgroup of patients with chronic NALD, the correlations remained significant between pancreatic PDFF and hepatic PDFF (R
=0.632, p<0.001) and between pancreatic PDFF and liver steatosis (R
=0.608, p<0.001); however, in the subgroup of patients with viral hepatitis these correlations were no longer significant.
Pancreatic fat deposition correlates with hepatic steatosis in patients with chronic NALD, but not in those with chronic viral hepatitis.</description><subject>Adult</subject><subject>Aged</subject><subject>Biopsy - standards</subject><subject>Chi-Square Distribution</subject><subject>Chronic Disease</subject><subject>Cross-Sectional Studies</subject><subject>Fatty Liver - diagnostic imaging</subject><subject>Fatty Liver - pathology</subject><subject>Female</subject><subject>Hepatitis, Viral, Human - diagnostic imaging</subject><subject>Humans</subject><subject>Lipomatosis - diagnostic imaging</subject><subject>Lipomatosis - pathology</subject><subject>Liver - pathology</subject><subject>Liver Diseases - complications</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Non-alcoholic Fatty Liver Disease - diagnostic imaging</subject><subject>Pancreatic Diseases - diagnostic imaging</subject><subject>Pancreatic Diseases - pathology</subject><subject>Statistics, Nonparametric</subject><subject>Young Adult</subject><issn>1578-178X</issn><issn>2173-5107</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE1Lw0AYhBdBbKm9e5I9ekncjyS7e5TiR6EiioInw5vNG7uSbmJ2q_bfG2k9Dcw8M4ch5IyzlDNeXH6kw08qGDcp5ylj6ohMea50wpV-nZB5CK4aw0KoguUnZCK5kSNdTMnb4xZ8dM3O-XcaIkLsggvUeRrXSFv3hQMFX9MevB0QAv12cU3vn5Z_SA_RoY97z66Hzjt76NQujDSekuMG2oDzg87Iy8318-IuWT3cLhdXq6QXnMckt8yAarSELAOoQOgKDQqLQmNVSaUZaxA0Z0YpIU0trW24LozNVV3pLJMzcrHf7Yfuc4shlhsXLLYteOy2oRRSaqYzM7Zn5PyAbqsN1mU_uA0Mu_L_E_kLoIxjww</recordid><startdate>202005</startdate><enddate>202005</enddate><creator>Vieira, J</creator><creator>Amorim, J</creator><creator>Martí-Bonmatí, L</creator><creator>Alberich-Bayarri, Á</creator><creator>França, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>202005</creationdate><title>Quantifying steatosis in the liver and pancreas with MRI in patient with chronic liver disease</title><author>Vieira, J ; Amorim, J ; Martí-Bonmatí, L ; Alberich-Bayarri, Á ; França, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-5c09a7f83a44aaba28be9e2ce28ebb37800fea810977239d3ccf1869c57db8443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; spa</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biopsy - standards</topic><topic>Chi-Square Distribution</topic><topic>Chronic Disease</topic><topic>Cross-Sectional Studies</topic><topic>Fatty Liver - diagnostic imaging</topic><topic>Fatty Liver - pathology</topic><topic>Female</topic><topic>Hepatitis, Viral, Human - diagnostic imaging</topic><topic>Humans</topic><topic>Lipomatosis - diagnostic imaging</topic><topic>Lipomatosis - pathology</topic><topic>Liver - pathology</topic><topic>Liver Diseases - complications</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Non-alcoholic Fatty Liver Disease - diagnostic imaging</topic><topic>Pancreatic Diseases - diagnostic imaging</topic><topic>Pancreatic Diseases - pathology</topic><topic>Statistics, Nonparametric</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vieira, J</creatorcontrib><creatorcontrib>Amorim, J</creatorcontrib><creatorcontrib>Martí-Bonmatí, L</creatorcontrib><creatorcontrib>Alberich-Bayarri, Á</creatorcontrib><creatorcontrib>França, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Radiologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vieira, J</au><au>Amorim, J</au><au>Martí-Bonmatí, L</au><au>Alberich-Bayarri, Á</au><au>França, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantifying steatosis in the liver and pancreas with MRI in patient with chronic liver disease</atitle><jtitle>Radiologia</jtitle><addtitle>Radiologia</addtitle><date>2020-05</date><risdate>2020</risdate><volume>62</volume><issue>3</issue><spage>222</spage><epage>228</epage><pages>222-228</pages><eissn>1578-178X</eissn><eissn>2173-5107</eissn><abstract>To compare pancreatic and hepatic steatosis quantified by proton density fat fraction (PDFF) on magnetic resonance imaging (MRI) in patients with chronic liver disease.
This cross-sectional study included 46 adult patients who underwent liver biopsy for chronic viral hepatitis (n=19) or other chronic non-alcoholic liver diseases (NALD) (n=27). Liver biopsy was used as the gold standard for diagnosing and grading hepatic steatosis. All patients underwent clinical evaluation and MRI with a multi-echo chemical shift-encoded (MECSE) gradient-echo sequence for liver and pancreas PDFF quantification. We used Spearman's correlation coefficient to determine the degree of association between hepatic PDFF and steatosis grade, and between pancreatic PDFF and steatosis grade and hepatic PDFF. To compare the chronic viral hepatitis group and the NALD group, we used t-tests for continuous or ordinal variables and chi-square tests for categorical variables.
Hepatic PDFF measurements correlated with steatosis grades (R
=0.875, p<0.001). Pancreatic PDFF correlated with hepatic steatosis grades (R
=0.573, p<0.001) and hepatic PDFF measurements (R
=0.536, p<0.001). In the subgroup of patients with chronic NALD, the correlations remained significant between pancreatic PDFF and hepatic PDFF (R
=0.632, p<0.001) and between pancreatic PDFF and liver steatosis (R
=0.608, p<0.001); however, in the subgroup of patients with viral hepatitis these correlations were no longer significant.
Pancreatic fat deposition correlates with hepatic steatosis in patients with chronic NALD, but not in those with chronic viral hepatitis.</abstract><cop>Spain</cop><pmid>31932016</pmid><doi>10.1016/j.rx.2019.11.007</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Biopsy - standards Chi-Square Distribution Chronic Disease Cross-Sectional Studies Fatty Liver - diagnostic imaging Fatty Liver - pathology Female Hepatitis, Viral, Human - diagnostic imaging Humans Lipomatosis - diagnostic imaging Lipomatosis - pathology Liver - pathology Liver Diseases - complications Magnetic Resonance Imaging - methods Male Middle Aged Non-alcoholic Fatty Liver Disease - diagnostic imaging Pancreatic Diseases - diagnostic imaging Pancreatic Diseases - pathology Statistics, Nonparametric Young Adult |
| title | Quantifying steatosis in the liver and pancreas with MRI in patient with chronic liver disease |
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