Quantifying steatosis in the liver and pancreas with MRI in patient with chronic liver disease

To compare pancreatic and hepatic steatosis quantified by proton density fat fraction (PDFF) on magnetic resonance imaging (MRI) in patients with chronic liver disease. This cross-sectional study included 46 adult patients who underwent liver biopsy for chronic viral hepatitis (n=19) or other chroni...

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Veröffentlicht in:Radiologia 2020-05, Vol.62 (3), p.222-228
Hauptverfasser: Vieira, J, Amorim, J, Martí-Bonmatí, L, Alberich-Bayarri, Á, França, M
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Sprache:eng ; spa
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Zusammenfassung:To compare pancreatic and hepatic steatosis quantified by proton density fat fraction (PDFF) on magnetic resonance imaging (MRI) in patients with chronic liver disease. This cross-sectional study included 46 adult patients who underwent liver biopsy for chronic viral hepatitis (n=19) or other chronic non-alcoholic liver diseases (NALD) (n=27). Liver biopsy was used as the gold standard for diagnosing and grading hepatic steatosis. All patients underwent clinical evaluation and MRI with a multi-echo chemical shift-encoded (MECSE) gradient-echo sequence for liver and pancreas PDFF quantification. We used Spearman's correlation coefficient to determine the degree of association between hepatic PDFF and steatosis grade, and between pancreatic PDFF and steatosis grade and hepatic PDFF. To compare the chronic viral hepatitis group and the NALD group, we used t-tests for continuous or ordinal variables and chi-square tests for categorical variables. Hepatic PDFF measurements correlated with steatosis grades (R =0.875, p
ISSN:1578-178X
2173-5107
DOI:10.1016/j.rx.2019.11.007