LncRNA PCAT1 promotes metastasis of endometrial carcinoma through epigenetical downregulation of E-cadherin associated with methyltransferase EZH2

LncRNA PCAT1 promotes metastasis of endometrial carcinoma through epigenetical downregulation of E-cadherin associated with methyltransferase EZH2

More than 140 thousands of women suffer from endometrial carcinoma in the worldwide, and over 40 thousand of the patients die before and after in surgery and chemoradiotherapy because of its metastasis. However, its molecular mechanism is much less known compared to other cancers. In this study, we...

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Veröffentlicht in:Life sciences (1973) 2020-02, Vol.243, p.117295
Hauptverfasser: Zhang, Chunhua, Shao, Shasha, Zhang, Yujian, Wang, Liyang, Liu, Jianzhong, Fang, Fang, Li, Peiquan, Wang, Bo
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biotechnology
Cadherins - physiology
Carcinoma
Cell Line, Tumor
Cell proliferation
Chemoradiotherapy
Down-regulation
Down-Regulation - genetics
E-cadherin
Endometrial Neoplasms - enzymology
Endometrial Neoplasms - genetics
Endometrial Neoplasms - pathology
Endometrium
Enhancer of Zeste Homolog 2 Protein - metabolism
Epigenesis, Genetic
Female
Histone methyltransferase
Humans
Immunoprecipitation
Metastases
Metastasis
Mice
Mice, Nude
Middle Aged
N-Cadherin
Neoplasm Metastasis - genetics
Non-coding RNA
Overexpression
Patients
Protein Binding
RNA, Long Noncoding - metabolism
RNA, Long Noncoding - physiology
Surgery
Tumorigenesis
Uterine cancer
Vimentin
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Zusammenfassung:More than 140 thousands of women suffer from endometrial carcinoma in the worldwide, and over 40 thousand of the patients die before and after in surgery and chemoradiotherapy because of its metastasis. However, its molecular mechanism is much less known compared to other cancers. In this study, we demonstrated that long non-coding RNA PCAT1 is dramatically increased in the tissues and plasma from endometrial carcinoma (EC) (n = 100, all p 
ISSN:0024-3205
1879-0631
1879-0631
DOI:10.1016/j.lfs.2020.117295