Pressure–impedance analysis: Assist the diagnosis and classification of ineffective esophageal motility disorder

Background and Aim We elucidated the clinical significance of distal contractile integral‐to‐esophageal impedance integral (EII) ratio (DCIIR) in ineffective esophageal motility (IEM) adult patients. Methods We recruited 101 patients with IEM (48.38 ± 1.58 years) and 42 matched healthy volunteers (44.28 ± 1.85 years) in this case–control study. All subjects underwent esophageal high‐resolution impedance manometry from October 2014 to May 2018. The diagnosis of IEM was based on the Chicago Classification version 3.0. The EII, EII ratio, and DCIIR were analyzed by matlab software. Results The EII, EII ratio, and DCIIR calculated at an impedance threshold of 1500 Ω (EII1500, EII ratio1500, and DCIIR1500, respectively) were significantly lower in the IEM group than in healthy controls (P