Stathmin 1 is highly expressed and associated with survival outcome in malignant adrenocortical tumours

Adrenocortical carcinoma (ACC) is an aggressive endocrine cancer with few molecular predictors of malignancy and survival, especially in paediatric patients. Stathmin 1 (STMN1) regulates microtubule dynamics and has been involved in the malignant phenotype of cancer cells. Recently, it was reported...

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Veröffentlicht in:	Investigational new drugs 2020-06, Vol.38 (3), p.899-908
Hauptverfasser:	dos Santos Passaia, Bárbara, Lima, Keli, Kremer, Jean Lucas, da Conceição, Barbara Brito, de Paula Mariani, Beatriz Marinho, da Silva, Jean Carlos Lipreri, Zerbini, Maria Claudia Nogueira, Fragoso, Maria Candida Barisson Villares, Machado-Neto, João Agostinho, Lotfi, Claudimara Ferini Pacicco
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma Biotechnology Cancer Cell adhesion & migration Cell culture Cell migration Clinical trials Gene expression Malignancy Medicine Medicine & Public Health mRNA Neuroendocrine tumors Oncology Paclitaxel Pediatrics Pharmacology/Toxicology Phenotypes PTEN-induced putative kinase Short Report Stathmin Survival Tumors
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Zusammenfassung:	Adrenocortical carcinoma (ACC) is an aggressive endocrine cancer with few molecular predictors of malignancy and survival, especially in paediatric patients. Stathmin 1 (STMN1) regulates microtubule dynamics and has been involved in the malignant phenotype of cancer cells. Recently, it was reported that STMN1 is highly expressed in ACC patients, and STMN1 silencing reduces the clonogenicity and migration of ACC cell lines. However, the prognostic significance of STMN1 and its therapeutic potential remain undefined in ACC. In the present study, STMN1 mRNA levels were significantly higher ( p
ISSN:	0167-6997 1573-0646
DOI:	10.1007/s10637-019-00846-9