Effects of ALOX5, IL6R and SFTPD gene polymorphisms on the risk of lung cancer: A case-control study in China

Effects of ALOX5, IL6R and SFTPD gene polymorphisms on the risk of lung cancer: A case-control study in China

•The IL6R rs4845626-T and rs4329505-C alleles were associated with a decreased risk of lung cancer.•The ALOX5 rs892690, rs745986 and rs2115819 were associated with an increased risk of lung cancer.•The SFTPD rs2245121 allele was correlated with an increased risk of lung cancer in smokers. ALOX5, IL6...

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Veröffentlicht in:International immunopharmacology 2020-02, Vol.79, p.106155-106155, Article 106155
Hauptverfasser: Wei, Xiaoping, Wang, Chen, Feng, Haiming, Li, Bing, Jiang, Peng, Yang, Jianbao, Zhu, Duojie, Zhang, Shaobo, Jin, Tao, Meng, Yuqi
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Alleles
Arachidonate 5-lipoxygenase (ALOX5)
Arachidonate 5-Lipoxygenase - genetics
Case-Control Studies
China
Cohort Studies
Female
Gene Frequency
Genes
Genetic Association Studies
Genotype
Genotypes
Health risk assessment
Health risks
Humans
Interleukin 6
Interleukin 6 receptor (IL6R)
Interleukin 6 receptors
Lung cancer
Lung Neoplasms - genetics
Male
Middle Aged
Nucleotides
Pathogenesis
Polymorphism, Single Nucleotide
Polymorphisms
Pulmonary Surfactant-Associated Protein D - genetics
Receptors, Interleukin-6 - genetics
Risk
Risk assessment
Risk management
Single-nucleotide polymorphism
Smoking
Surfactant protein D (SFTPD)
Tobacco smoke
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Zusammenfassung:•The IL6R rs4845626-T and rs4329505-C alleles were associated with a decreased risk of lung cancer.•The ALOX5 rs892690, rs745986 and rs2115819 were associated with an increased risk of lung cancer.•The SFTPD rs2245121 allele was correlated with an increased risk of lung cancer in smokers. ALOX5, IL6R and SFTPD are all immune related genes that may be involved in the development of lung cancer. We sought to explore the effect of polymorphisms of these genes on the risk of lung cancer. Six single nucleotide polymorphisms (SNPs) were genotyped using a MassARRAY platform in a case-control cohort including 550 patients with lung cancer and 550 healthy controls. The rs4845626-T and rs4329505-C alleles were associated with a decreased risk of lung cancer (p
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2019.106155