Protective effects of polydatin on multiple organ ischemia-reperfusion injury

[Display omitted] •Polydatin has a protective effect on multiple organ ischemia-reperfusion injury.•Polydatin is a new drug with great potential for anti-ischemic reperfusion injury.•The protection of PD on I/R injury is a synergistic effect of various mechanisms.•The protection of PD on I/R injury needs further exploration and verification. Polydatin(PD), a natural active ingredient isolated from traditional Chinese herb Polygonum cuspidatum, is also found in daily foods such as grapes and red wine. It might play a potential therapeutic role in human health through its anti-inflammatory, anti-oxidant, anti-ischemia injury, anti-apoptosis, conditioning blood lipids and other effects, which makes it increasingly become a hotspot of research. Various studies have shown that PD has a protective effect in the ischemia-reperfusion injury of heart, lungs, kidneys, gastrointestinal tract, cerebra and other organs. However, the specific mechanism of action is less and not completely clear. In this study, we aim to review the protective mechanism of PD in the ischemia-reperfusion injury of various organs, and provide inspiration for future studies.