Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study

The development of a new class of surfactants for membrane protein manipulation, "GNG amphiphiles", is reported. These amphiphiles display promising behavior for membrane proteins, as demonstrated recently by the high resolution structure of a sodium-pumping pyrophosphatase reported by Kel...

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Veröffentlicht in:	Chem. Commun 2013-03, Vol.49 (23), p.2287-2289
Hauptverfasser:	Chae, Pil Seok, Rana, Rohini R, Gotfryd, Kamil, Rasmussen, Søren G F, Kruse, Andrew C, Cho, Kyung Ho, Capaldi, Stefano, Carlsson, Emil, Kobilka, Brian, Loland, Claus J, Gether, Ulrik, Banerjee, Surajit, Byrne, Bernadette, Lee, John K, Gellman, Samuel H
Format:	Artikel
Sprache:	eng
Schlagworte:	chemical communication chemical compounds chemical reactions Detergents - chemistry enzymes Glucose - chemistry Glycols - chemistry membrane proteins Membrane Proteins - chemistry Membrane Proteins - metabolism Protein Stability Rhodobacter capsulatus - metabolism surfactants
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Beschreibung
Zusammenfassung:	The development of a new class of surfactants for membrane protein manipulation, "GNG amphiphiles", is reported. These amphiphiles display promising behavior for membrane proteins, as demonstrated recently by the high resolution structure of a sodium-pumping pyrophosphatase reported by Kellosalo et al. (Science, 2012, 337, 473).
ISSN:	1359-7345 1364-548X 1364-548X
DOI:	10.1039/c2cc36844g