Effects of ABCA1 gene polymorphisms on risk factors, susceptibility and severity of coronary artery disease

Effects of ABCA1 gene polymorphisms on risk factors, susceptibility and severity of coronary artery disease

BackgroundThe relationships between the rs1800976, rs4149313 and rs2230806 polymorphisms in ATP binding cassette protein A1 and severity of coronary artery disease (CAD) remain unclear.MethodsFour hundred and forty-two patients with CAD and 217 CAD-free subjects were enrolled in this study. The rs18...

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Veröffentlicht in:Postgraduate medical journal 2020-11, Vol.96 (1141), p.666-673
Hauptverfasser: Lu, Zhan, Luo, Zhi, Jia, Aimei, Muhammad, Irfan, Zeng, Wei, Shiganmo, Azhe, Chen, Xueli, Song, Yongyan
Format: Artikel
Sprache:eng
Schlagworte:
Blood pressure
Cardiovascular disease
Cholesterol
Coronary vessels
Cytokines
Drugs
Ethnicity
Glucose
Inflammation
Lipids
Lipoproteins
Medical imaging
Metabolism
Polymorphism
Polypeptides
Risk factors
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Zusammenfassung:BackgroundThe relationships between the rs1800976, rs4149313 and rs2230806 polymorphisms in ATP binding cassette protein A1 and severity of coronary artery disease (CAD) remain unclear.MethodsFour hundred and forty-two patients with CAD and 217 CAD-free subjects were enrolled in this study. The rs1800976, rs4149313 and rs2230806 polymorphisms were genotyped by PCR-RFLP. Severity of CAD was evaluated by Gensini score system, number of stenotic coronary vessels and extent of coronary stenosis.ResultsC allele of the rs1800976 polymorphism, G allele of the rs4149313 polymorphism and A allele of the rs2230806 polymorphism were found to be risk alleles for CAD (p
ISSN:0032-5473
1469-0756
DOI:10.1136/postgradmedj-2019-136917