A functional variant near XCL1 gene improves breast cancer survival via promoting cancer immunity

Most genome‐wide association studies (GWASs) identify genetic variants for breast cancer occurrence. In contrast, few are for recurrence and mortality. We conducted a GWAS on breast cancer survival after diagnosis in estrogen receptor‐positive patients, including 953 Taiwanese patients with 159 even...

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Veröffentlicht in:	International journal of cancer 2020-04, Vol.146 (8), p.2182-2193
Hauptverfasser:	Chou, Wen‐Cheng, Hsiung, Chia‐Ni, Chen, Wei‐Ting, Tseng, Ling‐Ming, Wang, Hui‐Chun, Chu, Hou‐Wei, Hou, Ming‐Feng, Yu, Jyh‐Cherng, Shen, Chen‐Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alleles Breast cancer breast cancer survival Breast Neoplasms - genetics Breast Neoplasms - immunology Breast Neoplasms - pathology Cancer Cell Cycle Proteins - genetics Cell Cycle Proteins - immunology Chemokines Chemokines, C - biosynthesis Chemokines, C - genetics Chemokines, C - immunology CRISPR Dendritic cells Dendritic Cells - immunology Dendritic Cells - pathology Female Gene expression Gene Expression Regulation, Neoplastic Genetic diversity Genome editing Genome-wide association studies Genome-Wide Association Study Genomes Humans Medical research Mendelian randomization Middle Aged MYBL2 Proportional Hazards Models Quantitative Trait Loci Single-nucleotide polymorphism Trans-Activators - genetics Trans-Activators - immunology type 1 dendritic cells XCL1 Young Adult
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Zusammenfassung:	Most genome‐wide association studies (GWASs) identify genetic variants for breast cancer occurrence. In contrast, few are for recurrence and mortality. We conducted a GWAS on breast cancer survival after diagnosis in estrogen receptor‐positive patients, including 953 Taiwanese patients with 159 events. Through Cox proportional hazard models estimation, we identified 24 risk SNPs with p
ISSN:	0020-7136 1097-0215
DOI:	10.1002/ijc.32855