Magnetic resonance fingerprinting for simultaneous renal T1 and T 2 mapping in a single breath-hold

PURPOSETo evaluate the use of magnetic resonance fingerprinting (MRF) for simultaneous quantification of T 1 and T 2 ∗ in a single breath-hold in the kidneys. METHODSThe proposed kidney MRF sequence was based on MRF echo-planar imaging. Thirty-five measurements per slice and overall 4 slices were measured in 15.4 seconds. Group matching was performed for in-line quantification of T 1 and T 2 ∗ . Images were acquired in a phantom and 8 healthy volunteers in coronal orientation. To evaluate our approach, region of interests were drawn in the kidneys to calculate mean values and standard deviations of the T 1 and T 2 ∗ times. Precision was calculated across multiple repeated MRF scans. Gaussian filtering is applied on baseline images to improve SNR and match stability. RESULTST 1 and T 2 ∗ times acquired with MRF in the phantom showed good agreement with reference measurements and conventional mapping methods with deviations of less than 5% for T 1 and less than 10% for T 2 ∗ . Baseline images in vivo were free of artifacts and relaxation times yielded good agreement with conventional methods and literature (deviation T 1 : 7 ± 4 % , T 2 ∗ : 6 ± 3 % ). CONCLUSIONSIn this feasibility study, the proposed renal MRF sequence resulted in accurate T 1 and T 2 ∗ quantification in a single breath-hold.