Higher density of stromal M2 macrophages in breast ductal carcinoma in situ predicts recurrence
Immune response can affect tumour progression and treatment outcome. This study investigated the potential of stromal macrophages around ductal carcinoma in situ (DCIS) in predicting recurrence and progression. CD68 and CD163 expression of macrophages in DCIS from 198 patients was determined by immu...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2020-06, Vol.476 (6), p.825-833 |
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| container_title | Virchows Archiv : an international journal of pathology |
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| creator | Chen, Xiao-Yang Thike, Aye Aye Md Nasir, Nur Diyana Koh, Valerie Cui Yun Bay, Boon Huat Tan, Puay Hoon |
| description | Immune response can affect tumour progression and treatment outcome. This study investigated the potential of stromal macrophages around ductal carcinoma in situ (DCIS) in predicting recurrence and progression. CD68 and CD163 expression of macrophages in DCIS from 198 patients was determined by immunohistochemistry. Disease free survival (DFS), clinicopathological parameters and biomarker expression were correlated with the densities of both CD68
+
and CD163
+
macrophages. High CD68
+
macrophage density was associated with high nuclear grade (
p
|
| doi_str_mv | 10.1007/s00428-019-02735-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2333605669</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2333605669</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-f0b3718eb823f0db37c709093e27253cd7483a927c36a9807d45c17e35f540363</originalsourceid><addsrcrecordid>eNp9kD1PwzAURS0EoqXwBxiQJRaWwLNfEjsjQnxJRSwwW67z0qZqkmInQ_89Li0gMTBZ1j332jqMnQu4FgDqJgCkUicgigSkwiwRB2wsUpSJRFCHbAxFmiU5CjViJyEsAaTQIj9mIxS6UFrCmJmner4gz0tqQ91veFfx0PuusSv-Inljne_WCzunwOuWzzzZ0PNycH3MnfWubiO6jWJ54GtPZe36wD25wXtqHZ2yo8quAp3tzwl7f7h_u3tKpq-Pz3e308ShyvqkghkqoWmmJVZQxotTUECBJJXM0JUq1WgLqRzmttCgyjRzQhFmVZYC5jhhV7vdte8-Bgq9aergaLWyLXVDMBIRc8jyvIjo5R902Q2-jb8zMo3KlJJ6Oyh3VDQQgqfKrH3dWL8xAsxWv9npN1G_-dJvRCxd7KeHWUPlT-XbdwRwB4QYtXPyv2__M_sJtIaOqw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2409477286</pqid></control><display><type>article</type><title>Higher density of stromal M2 macrophages in breast ductal carcinoma in situ predicts recurrence</title><source>SpringerNature Journals</source><creator>Chen, Xiao-Yang ; Thike, Aye Aye ; Md Nasir, Nur Diyana ; Koh, Valerie Cui Yun ; Bay, Boon Huat ; Tan, Puay Hoon</creator><creatorcontrib>Chen, Xiao-Yang ; Thike, Aye Aye ; Md Nasir, Nur Diyana ; Koh, Valerie Cui Yun ; Bay, Boon Huat ; Tan, Puay Hoon</creatorcontrib><description>Immune response can affect tumour progression and treatment outcome. This study investigated the potential of stromal macrophages around ductal carcinoma in situ (DCIS) in predicting recurrence and progression. CD68 and CD163 expression of macrophages in DCIS from 198 patients was determined by immunohistochemistry. Disease free survival (DFS), clinicopathological parameters and biomarker expression were correlated with the densities of both CD68
+
and CD163
+
macrophages. High CD68
+
macrophage density was associated with high nuclear grade (
p
< 0.001), oestrogen receptor (ER) negativity (
p
= 0.029), progesterone receptor (PR) negativity (
p
= 0.008) and human epidermal growth factor receptor 2 (HER2) positivity (
p
< 0.001). High CD163
+
macrophage density was associated with high nuclear grade (
p
= 0.003), microinvasion (
p
= 0.01), ER negativity (
p
< 0.001), PR negativity (
p
= 0.001), HER2 positivity (
p
= 0.001) and triple negativity (
p
= 0.022). DCIS with higher CD68
+
macrophage density disclosed significantly worse DFS for ipsilateral invasive recurrence (
p
= 0.004) and is affirmed by multivariate Cox regression analysis (95% CI 1.126–5.102, HR = 2.397,
p
= 0.023). DCIS with higher CD163
+
macrophage density showed significantly worse DFS for both recurrence (
p
= 0.001) and ipsilateral invasive recurrence (
p
= 0.001). These findings, for CD163
+
macrophage density, were affirmed by multivariate Cox regression analysis respectively for both recurrence (95% CI 1.210–2.293, HR = 1.880,
p
= 0.005) and ipsilateral invasive recurrence (95% CI 1.122–5.176, HR = 2.410,
p
= 0.024). This study demonstrated that DCIS with higher macrophage density was associated with poorer prognostic parameters, while DCIS with higher CD163
+
macrophage density predicted both recurrence and ipsilateral invasive recurrence.</description><identifier>ISSN: 0945-6317</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s00428-019-02735-1</identifier><identifier>PMID: 31897820</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biomarkers ; Breast ; Breast cancer ; CD163 antigen ; Density ; Epidermal growth factor ; ErbB-2 protein ; Growth factors ; Immune response ; Immune system ; Immunohistochemistry ; Invasiveness ; Macrophages ; Medicine ; Medicine & Public Health ; Multivariate analysis ; Original Article ; Parameters ; Pathology ; Progesterone ; Receptors ; Regression analysis ; Tumors</subject><ispartof>Virchows Archiv : an international journal of pathology, 2020-06, Vol.476 (6), p.825-833</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-f0b3718eb823f0db37c709093e27253cd7483a927c36a9807d45c17e35f540363</citedby><cites>FETCH-LOGICAL-c375t-f0b3718eb823f0db37c709093e27253cd7483a927c36a9807d45c17e35f540363</cites><orcidid>0000-0001-5897-413X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00428-019-02735-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00428-019-02735-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31897820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Xiao-Yang</creatorcontrib><creatorcontrib>Thike, Aye Aye</creatorcontrib><creatorcontrib>Md Nasir, Nur Diyana</creatorcontrib><creatorcontrib>Koh, Valerie Cui Yun</creatorcontrib><creatorcontrib>Bay, Boon Huat</creatorcontrib><creatorcontrib>Tan, Puay Hoon</creatorcontrib><title>Higher density of stromal M2 macrophages in breast ductal carcinoma in situ predicts recurrence</title><title>Virchows Archiv : an international journal of pathology</title><addtitle>Virchows Arch</addtitle><addtitle>Virchows Arch</addtitle><description>Immune response can affect tumour progression and treatment outcome. This study investigated the potential of stromal macrophages around ductal carcinoma in situ (DCIS) in predicting recurrence and progression. CD68 and CD163 expression of macrophages in DCIS from 198 patients was determined by immunohistochemistry. Disease free survival (DFS), clinicopathological parameters and biomarker expression were correlated with the densities of both CD68
+
and CD163
+
macrophages. High CD68
+
macrophage density was associated with high nuclear grade (
p
< 0.001), oestrogen receptor (ER) negativity (
p
= 0.029), progesterone receptor (PR) negativity (
p
= 0.008) and human epidermal growth factor receptor 2 (HER2) positivity (
p
< 0.001). High CD163
+
macrophage density was associated with high nuclear grade (
p
= 0.003), microinvasion (
p
= 0.01), ER negativity (
p
< 0.001), PR negativity (
p
= 0.001), HER2 positivity (
p
= 0.001) and triple negativity (
p
= 0.022). DCIS with higher CD68
+
macrophage density disclosed significantly worse DFS for ipsilateral invasive recurrence (
p
= 0.004) and is affirmed by multivariate Cox regression analysis (95% CI 1.126–5.102, HR = 2.397,
p
= 0.023). DCIS with higher CD163
+
macrophage density showed significantly worse DFS for both recurrence (
p
= 0.001) and ipsilateral invasive recurrence (
p
= 0.001). These findings, for CD163
+
macrophage density, were affirmed by multivariate Cox regression analysis respectively for both recurrence (95% CI 1.210–2.293, HR = 1.880,
p
= 0.005) and ipsilateral invasive recurrence (95% CI 1.122–5.176, HR = 2.410,
p
= 0.024). This study demonstrated that DCIS with higher macrophage density was associated with poorer prognostic parameters, while DCIS with higher CD163
+
macrophage density predicted both recurrence and ipsilateral invasive recurrence.</description><subject>Biomarkers</subject><subject>Breast</subject><subject>Breast cancer</subject><subject>CD163 antigen</subject><subject>Density</subject><subject>Epidermal growth factor</subject><subject>ErbB-2 protein</subject><subject>Growth factors</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunohistochemistry</subject><subject>Invasiveness</subject><subject>Macrophages</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multivariate analysis</subject><subject>Original Article</subject><subject>Parameters</subject><subject>Pathology</subject><subject>Progesterone</subject><subject>Receptors</subject><subject>Regression analysis</subject><subject>Tumors</subject><issn>0945-6317</issn><issn>1432-2307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kD1PwzAURS0EoqXwBxiQJRaWwLNfEjsjQnxJRSwwW67z0qZqkmInQ_89Li0gMTBZ1j332jqMnQu4FgDqJgCkUicgigSkwiwRB2wsUpSJRFCHbAxFmiU5CjViJyEsAaTQIj9mIxS6UFrCmJmner4gz0tqQ91veFfx0PuusSv-Inljne_WCzunwOuWzzzZ0PNycH3MnfWubiO6jWJ54GtPZe36wD25wXtqHZ2yo8quAp3tzwl7f7h_u3tKpq-Pz3e308ShyvqkghkqoWmmJVZQxotTUECBJJXM0JUq1WgLqRzmttCgyjRzQhFmVZYC5jhhV7vdte8-Bgq9aergaLWyLXVDMBIRc8jyvIjo5R902Q2-jb8zMo3KlJJ6Oyh3VDQQgqfKrH3dWL8xAsxWv9npN1G_-dJvRCxd7KeHWUPlT-XbdwRwB4QYtXPyv2__M_sJtIaOqw</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Chen, Xiao-Yang</creator><creator>Thike, Aye Aye</creator><creator>Md Nasir, Nur Diyana</creator><creator>Koh, Valerie Cui Yun</creator><creator>Bay, Boon Huat</creator><creator>Tan, Puay Hoon</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature 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density of stromal M2 macrophages in breast ductal carcinoma in situ predicts recurrence</title><author>Chen, Xiao-Yang ; Thike, Aye Aye ; Md Nasir, Nur Diyana ; Koh, Valerie Cui Yun ; Bay, Boon Huat ; Tan, Puay Hoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-f0b3718eb823f0db37c709093e27253cd7483a927c36a9807d45c17e35f540363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biomarkers</topic><topic>Breast</topic><topic>Breast cancer</topic><topic>CD163 antigen</topic><topic>Density</topic><topic>Epidermal growth factor</topic><topic>ErbB-2 protein</topic><topic>Growth factors</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunohistochemistry</topic><topic>Invasiveness</topic><topic>Macrophages</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multivariate analysis</topic><topic>Original Article</topic><topic>Parameters</topic><topic>Pathology</topic><topic>Progesterone</topic><topic>Receptors</topic><topic>Regression analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Xiao-Yang</creatorcontrib><creatorcontrib>Thike, Aye Aye</creatorcontrib><creatorcontrib>Md Nasir, Nur Diyana</creatorcontrib><creatorcontrib>Koh, Valerie Cui Yun</creatorcontrib><creatorcontrib>Bay, Boon Huat</creatorcontrib><creatorcontrib>Tan, Puay Hoon</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology 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BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Virchows Archiv : an international journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Xiao-Yang</au><au>Thike, Aye Aye</au><au>Md Nasir, Nur Diyana</au><au>Koh, Valerie Cui Yun</au><au>Bay, Boon Huat</au><au>Tan, Puay Hoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Higher density of stromal M2 macrophages in breast ductal carcinoma in situ predicts recurrence</atitle><jtitle>Virchows Archiv : an international journal of pathology</jtitle><stitle>Virchows Arch</stitle><addtitle>Virchows Arch</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>476</volume><issue>6</issue><spage>825</spage><epage>833</epage><pages>825-833</pages><issn>0945-6317</issn><eissn>1432-2307</eissn><abstract>Immune response can affect tumour progression and treatment outcome. This study investigated the potential of stromal macrophages around ductal carcinoma in situ (DCIS) in predicting recurrence and progression. CD68 and CD163 expression of macrophages in DCIS from 198 patients was determined by immunohistochemistry. Disease free survival (DFS), clinicopathological parameters and biomarker expression were correlated with the densities of both CD68
+
and CD163
+
macrophages. High CD68
+
macrophage density was associated with high nuclear grade (
p
< 0.001), oestrogen receptor (ER) negativity (
p
= 0.029), progesterone receptor (PR) negativity (
p
= 0.008) and human epidermal growth factor receptor 2 (HER2) positivity (
p
< 0.001). High CD163
+
macrophage density was associated with high nuclear grade (
p
= 0.003), microinvasion (
p
= 0.01), ER negativity (
p
< 0.001), PR negativity (
p
= 0.001), HER2 positivity (
p
= 0.001) and triple negativity (
p
= 0.022). DCIS with higher CD68
+
macrophage density disclosed significantly worse DFS for ipsilateral invasive recurrence (
p
= 0.004) and is affirmed by multivariate Cox regression analysis (95% CI 1.126–5.102, HR = 2.397,
p
= 0.023). DCIS with higher CD163
+
macrophage density showed significantly worse DFS for both recurrence (
p
= 0.001) and ipsilateral invasive recurrence (
p
= 0.001). These findings, for CD163
+
macrophage density, were affirmed by multivariate Cox regression analysis respectively for both recurrence (95% CI 1.210–2.293, HR = 1.880,
p
= 0.005) and ipsilateral invasive recurrence (95% CI 1.122–5.176, HR = 2.410,
p
= 0.024). This study demonstrated that DCIS with higher macrophage density was associated with poorer prognostic parameters, while DCIS with higher CD163
+
macrophage density predicted both recurrence and ipsilateral invasive recurrence.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31897820</pmid><doi>10.1007/s00428-019-02735-1</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5897-413X</orcidid></addata></record> |
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| ispartof | Virchows Archiv : an international journal of pathology, 2020-06, Vol.476 (6), p.825-833 |
| issn | 0945-6317 1432-2307 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2333605669 |
| source | SpringerNature Journals |
| subjects | Biomarkers Breast Breast cancer CD163 antigen Density Epidermal growth factor ErbB-2 protein Growth factors Immune response Immune system Immunohistochemistry Invasiveness Macrophages Medicine Medicine & Public Health Multivariate analysis Original Article Parameters Pathology Progesterone Receptors Regression analysis Tumors |
| title | Higher density of stromal M2 macrophages in breast ductal carcinoma in situ predicts recurrence |
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