Higher density of stromal M2 macrophages in breast ductal carcinoma in situ predicts recurrence

Immune response can affect tumour progression and treatment outcome. This study investigated the potential of stromal macrophages around ductal carcinoma in situ (DCIS) in predicting recurrence and progression. CD68 and CD163 expression of macrophages in DCIS from 198 patients was determined by immu...

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Veröffentlicht in:	Virchows Archiv : an international journal of pathology 2020-06, Vol.476 (6), p.825-833
Hauptverfasser:	Chen, Xiao-Yang, Thike, Aye Aye, Md Nasir, Nur Diyana, Koh, Valerie Cui Yun, Bay, Boon Huat, Tan, Puay Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Breast Breast cancer CD163 antigen Density Epidermal growth factor ErbB-2 protein Growth factors Immune response Immune system Immunohistochemistry Invasiveness Macrophages Medicine Medicine & Public Health Multivariate analysis Original Article Parameters Pathology Progesterone Receptors Regression analysis Tumors
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Zusammenfassung:	Immune response can affect tumour progression and treatment outcome. This study investigated the potential of stromal macrophages around ductal carcinoma in situ (DCIS) in predicting recurrence and progression. CD68 and CD163 expression of macrophages in DCIS from 198 patients was determined by immunohistochemistry. Disease free survival (DFS), clinicopathological parameters and biomarker expression were correlated with the densities of both CD68 + and CD163 + macrophages. High CD68 + macrophage density was associated with high nuclear grade ( p
ISSN:	0945-6317 1432-2307
DOI:	10.1007/s00428-019-02735-1