Absolute configuration of chiral polar crystals
A method is described for direct determination of absolute configuration of chiral polar crystals, based on changes in crystal habit induced by tailor-made impurities. The method embodies the assignment of the direction of the chiral substrate molecule with respect to the crystal polar axis based on...
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| Veröffentlicht in: | Nature (London) 1982-01, Vol.296 (5852), p.27-34 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A method is described for direct determination of absolute configuration of chiral polar crystals, based on changes in crystal habit induced by tailor-made impurities. The method embodies the assignment of the direction of the chiral substrate molecule with respect to the crystal polar axis based on differences in the hemihedral faces of the substrate crystals as grown from solution in the presence and absence of impurities. The molecular packing requirements and the choice of impurities for application of this method in lysine and trans-cinnamoyl alanine are outlined. |
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| ISSN: | 0028-0836 1476-4687 |
| DOI: | 10.1038/296027a0 |