Fetal Oxygen and Glucose Consumption in Human Pregnancy Complicated by Fetal Growth Restriction

Fetal Oxygen and Glucose Consumption in Human Pregnancy Complicated by Fetal Growth Restriction

In healthy pregnancy, glucose and oxygen availability are essential for fetal growth and well being. However, how substrate delivery and fetal uptake are affected in human pregnancy complicated by fetal growth restriction (FGR) is still unknown. Here, we show that the human FGR fetus has a strikingl...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2020-03, Vol.75 (3), p.748-754
Hauptverfasser: Cetin, Irene, Taricco, Emanuela, Mandò, Chiara, Radaelli, Tatjana, Boito, Simona, Nuzzo, Anna Maria, Giussani, Dino A.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Blood Flow Velocity
Female
Fetal Growth Retardation - metabolism
Fetus - metabolism
Gestational Age
Glucose - metabolism
Humans
Oxygen - metabolism
Oxygen Consumption
Placenta - blood supply
Pregnancy
Severity of Illness Index
Umbilical Arteries
Umbilical Veins
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:In healthy pregnancy, glucose and oxygen availability are essential for fetal growth and well being. However, how substrate delivery and fetal uptake are affected in human pregnancy complicated by fetal growth restriction (FGR) is still unknown. Here, we show that the human FGR fetus has a strikingly reduced umbilical uptake of both oxygen and glucose. In 30 healthy term and 32 FGR human pregnancies, umbilical volume flow (Qumb) and parallel umbilical vein (uv) and artery (ua) blood samples were obtained at elective Cesarean section to calculate fetal glucose and oxygen uptake as Qumb · Δ (uv−ua) differences. Umbilical blood flow was significantly lower in FGR pregnancy (−63%; P
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.119.13727