Antiproliferative activity of diarylnaphthylpyrrolidine derivative via dual target inhibition

Breast cancer is the second leading cause of deaths in women globally. Present communication deals with design and synthesis of a few diarylnaphthyls as possible anti-breast cancer agents. Among the thirty three representatives with significant antiproliferative activity compounds 23 and 50 were quite efficacious against human breast cancer cells. Compound 50 induced apoptosis in both MCF-7 and MDA-MB-231 cells and exerted S phase and G2/M phase arrest respectively via distinct mechanistic pathways. It showed moderate microtubule destabilization. Further, it exhibited DNA topoisomerase-II inhibition effect in MCF-7 cells. It was well tolerable and found safe up to 300 mg/kg dose in Swiss albino mice. The dual action antiproliferative effect of compound 50 is quite interesting and warrants for future development. To create your abstract, type over the instructions in the template box below. Fonts or abstract dimensions should not be changed or altered. [Display omitted] •Three distinct pharmacophores on arylnaphthalene core-designed and synthesized.•Thirty three analogues exhibited potential antiproliferative activity.•Compound 50: novel, active against both ER+ & ER-breast cancer.•Target: Dual action; antitubulin and Topo-II inhibition.•Safety: in-vivo acute toxicity-safe up to 300 mg/kg dose.