Mesoporous carbon‑manganese nanocomposite for multiple imaging guided oxygen-elevated synergetic therapy

Despite of the extensive application of photodynamic therapy (PDT)nowadays, several restrictions have emerged such as hydrophobility, undesired phototoxicity and low selectivity of photosensitizer as well as the hypoxic tumor microenvironment. To address these challenges, a multifunctional mesoporous carbon‑manganese nanocomposite (MC-MnO2) is developed to load Chlorin e6 (Ce6) with a high loading capacity. The MC-MnO2 can prevent Ce6 from being activated by the sunlight to reduce unintentional phototoxicity significantly and realize the hypoxia relief via reacting with the H2O2 overexpressed in tumor tissue, meanwhile, the reduced product Mn2+ ion could act as a T1/T2-weighted MRI contrast. Based on the broad absorption of MC-MnO2 within the range of NIR, the nanoparticle has the potential for serving as a photothermal agent and photoacoustic imaging (PAI) agent. The PEG and iRGD are further decorated on MC-MnO2 (iPMC-MnO2) to improve the biocompatibility, targeting and penetration of the nanoparticle. Taking full advantage of the good photothermal effect of iPMC-MnO2, the photothermal therapy (PTT) and enhanced PDT are subtly integrated into one system, developing an intelligent multimodal diagnostic and therapeutic nanoplatform and realizing our “one nanoparticle fits all” dream. [Display omitted]