Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins

Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins

We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and import no detectable inheritable effect at clonal l...

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Veröffentlicht in:European journal of immunology 2020-05, Vol.50 (5), p.748-751
Hauptverfasser: Heikkilä, Nelli, Vanhanen, Reetta, Yohannes, Dawit A., Saavalainen, Päivi, Meri, Seppo, Jokiranta, T. Sakari, Jarva, Hanna, Mattila, Ilkka P., Hamm, David, Sormunen, Silja, Saramäki, Jari, Arstila, T. Petteri
Format: Artikel
Sprache:eng
Schlagworte:
CDR3
genetics
Lymphocytes T
Stochasticity
T cell receptors
TCR repertoire
thymic selection
Thymus
Twins
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Zusammenfassung:We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and import no detectable inheritable effect at clonal level.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.201948404