Application of P(jv-a) CO2 in monitoring cerebral oxygen supply-demand balance in injured brain

•SjvO2 is significantly increased at different time points after hyperventilation.•(P(jv-a)CO2) and CBF show negative correlation in acute brain injury and spontaneous intracerebral hemorrhage groups.•P(jv-a)CO2 and CBF show positive correlation in acute cerebral infarction group.•Serial P(jv-a) CO2 analysis combing with SjvO2 can be utilized to monitor the change of CBF. Transcranial Doppler sonography (TCD) assayed cerebral blood flow (CBF) may vary between different intracranial pathologies. Blood gas analysis of the jugular bulb provides a novel way to estimate the global relationship between CBF and oxygen metabolism. In this study, 25 patients with brain trauma, spontaneous intracerebral hemorrhage, and acute cerebral infarction were recruited. Jugular venous oxygen saturation (SjvO2) increased significantly at different time points after hyperventilation (p