Ionizing Radiation Decreases Veratridine-Stimulated Uptake of Sodium in Rat Brain Synaptosomes

Veratridine-stimulated uptake of sodium-22 in brain synaptosomes was significantly reduced by ionizing radiation over a dose range of 10 to 1000 rads. The response was dose-dependent and involved a decrease in the maximum effect of veratridine on uptake. The central nervous system may be more sensit...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1983-06, Vol.220 (4601), p.1073-1074
Hauptverfasser:	Wixon, Henry N., Hunt, Walter A.
Format:	Artikel
Sprache:	eng
Schlagworte:	560152 - Radiation Effects on Animals- Animals ALKALI METAL ISOTOPES Animals ANTIGENS BETA DECAY RADIOISOTOPES BETA-PLUS DECAY RADIOISOTOPES BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BODY BRAIN Brain - drug effects Brain - radiation effects Brain research Cell membranes CENTRAL NERVOUS SYSTEM Dose response relationship Dose-Response Relationship, Drug Dose-Response Relationship, Radiation DOSE-RESPONSE RELATIONSHIPS Electrons Ion Channels - drug effects Ion Channels - radiation effects Ionizing radiation IONIZING RADIATIONS ISOTOPES LIGHT NUCLEI Male MATERIALS MEDICINE NERVOUS SYSTEM NEUROLOGY NUCLEI ODD-ODD NUCLEI ORGANS Radiation dosage Radiation dose response relationship RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RADIOISOTOPES RADIOSENSITIVITY Rats Rats, Inbred Strains Sodium Sodium - metabolism SODIUM 22 Sodium channels SODIUM ISOTOPES Synapses Synaptosomes Synaptosomes - drug effects Synaptosomes - radiation effects TOXIC MATERIALS TOXINS UPTAKE veratridine Veratridine - pharmacology Veratrine - analogs & derivatives YEARS LIVING RADIOISOTOPES
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Zusammenfassung:	Veratridine-stimulated uptake of sodium-22 in brain synaptosomes was significantly reduced by ionizing radiation over a dose range of 10 to 1000 rads. The response was dose-dependent and involved a decrease in the maximum effect of veratridine on uptake. The central nervous system may be more sensitive to ionizing radiation than generally thought, perhaps through a loss of the ability of the sodium channel to respond properly to stimulation.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.6302846