A Fluorescence-Based High-Throughput Screening Method for Olefin Metathesis Using a Ratiometric Fluorescent Probe

A Fluorescence-Based High-Throughput Screening Method for Olefin Metathesis Using a Ratiometric Fluorescent Probe

(Z)-1,8-Di­(pyren-1-yl)­oct-4-ene (1) was prepared as a probe for olefin metathesis. The conversions of substrate by olefin metathesis under various conditions were calculated using the ratiometric fluorescence intensity change of 1. The conversions calculated by 1 and gas chromatography were consis...

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Veröffentlicht in:Organic letters 2020-03, Vol.22 (5), p.1703-1708
Hauptverfasser: Noh, Hyeongju, Lim, Taeho, Park, Byoung Yong, Han, Min Su
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes - chemistry
Fluorescence
Fluorescent Dyes - chemistry
High-Throughput Screening Assays
Molecular Structure
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Zusammenfassung:(Z)-1,8-Di­(pyren-1-yl)­oct-4-ene (1) was prepared as a probe for olefin metathesis. The conversions of substrate by olefin metathesis under various conditions were calculated using the ratiometric fluorescence intensity change of 1. The conversions calculated by 1 and gas chromatography were consistent. These results show that conversions of olefin metathesis can be simply obtained from the fluorescence change of 1 and this method can be applied to the high-throughput screening (HTS) method for various olefin metathesis.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b04462