Protein kinase D2 regulates epithelial sodium channel activity and aldosterone non-genomic responses in renal cortical collecting duct cells

Protein kinase D2 (PKD2) is a serine/threonine protein kinase which plays an important role in vesicle fission at the trans-Golgi network (TGN) to coordinate subcellular trafficking with gene expression. We found that in the rat kidney, PKD2 is specifically expressed in collecting duct principal cel...

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Veröffentlicht in:	Steroids 2020-03, Vol.155, p.108553-108553, Article 108553
Hauptverfasser:	Thomas, Warren, Dooley, Ruth, Quinn, Sinead, Robles, Manuel Yusef, Harvey, Brian J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldosterone Aldosterone - blood Aldosterone - pharmacology Animals Cells, Cultured Disease Models, Animal ENaC Epithelial Sodium Channels - metabolism Kidney CCD Kidney Tubules, Collecting - drug effects Kidney Tubules, Collecting - metabolism Male Mice Mice, Transgenic Phosphorylation PKD2 Protein kinase D Protein Kinase Inhibitors - pharmacology Protein Kinases - metabolism Rats Rats, Sprague-Dawley Renal Na+ reabsorption RNA, Small Interfering - pharmacology
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