Protein kinase D2 regulates epithelial sodium channel activity and aldosterone non-genomic responses in renal cortical collecting duct cells

Protein kinase D2 regulates epithelial sodium channel activity and aldosterone non-genomic responses in renal cortical collecting duct cells

Protein kinase D2 (PKD2) is a serine/threonine protein kinase which plays an important role in vesicle fission at the trans-Golgi network (TGN) to coordinate subcellular trafficking with gene expression. We found that in the rat kidney, PKD2 is specifically expressed in collecting duct principal cel...

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Veröffentlicht in:Steroids 2020-03, Vol.155, p.108553-108553, Article 108553
Hauptverfasser: Thomas, Warren, Dooley, Ruth, Quinn, Sinead, Robles, Manuel Yusef, Harvey, Brian J.
Format: Artikel
Sprache:eng
Schlagworte:
Aldosterone
Aldosterone - blood
Aldosterone - pharmacology
Animals
Cells, Cultured
Disease Models, Animal
ENaC
Epithelial Sodium Channels - metabolism
Kidney CCD
Kidney Tubules, Collecting - drug effects
Kidney Tubules, Collecting - metabolism
Male
Mice
Mice, Transgenic
Phosphorylation
PKD2
Protein kinase D
Protein Kinase Inhibitors - pharmacology
Protein Kinases - metabolism
Rats
Rats, Sprague-Dawley
Renal Na+ reabsorption
RNA, Small Interfering - pharmacology
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Zusammenfassung:Protein kinase D2 (PKD2) is a serine/threonine protein kinase which plays an important role in vesicle fission at the trans-Golgi network (TGN) to coordinate subcellular trafficking with gene expression. We found that in the rat kidney, PKD2 is specifically expressed in collecting duct principal cells predominantly at the apical membrane and with lower basal expression in cytosolic compartments. When rats were maintained on a Na+ depleted diet (
ISSN:0039-128X
1878-5867
DOI:10.1016/j.steroids.2019.108553