An automated modular assembly line for drugs in a miniaturized plant

An automated modular assembly line for drugs in a miniaturized plant

We report here a fully automated, end-to-end, integrated continuous manufacturing process for a small-molecule generic medication with built-in quality assurance. The entire process fits into a box of 30.7 m 2 modular footprint and a total residence time of less than 30 h, with a throughput up to 40...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2020-01, Vol.56 (7), p.126-129
Hauptverfasser: Hu, Chuntian, Testa, Christopher J, Wu, Wei, Shvedova, Khrystyna, Shen, Dongying Erin, Sayin, Ridade, Halkude, Bhakti S, Casati, Federica, Hermant, Paul, Ramnath, Anjana, Born, Stephen C, Takizawa, Bayan, O'Connor, Thomas F, Yang, Xiaochuan, Ramanujam, Sukumar, Mascia, Salvatore
Format: Artikel
Sprache:eng
Schlagworte:
Assembly lines
Automation
Automobile industry
Drug Industry - instrumentation
Drug Industry - methods
Pharmaceutical Preparations - chemical synthesis
Quality assurance
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Beschreibung
Zusammenfassung:We report here a fully automated, end-to-end, integrated continuous manufacturing process for a small-molecule generic medication with built-in quality assurance. The entire process fits into a box of 30.7 m 2 modular footprint and a total residence time of less than 30 h, with a throughput up to 40.3 × 10 6 tablets per year. Modular assembly line: a promising approach to reduce drug shortages, assure quality, and improve affordability.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc06945c