Low-dose dynamic myocardial perfusion imaging by CZT-SPECT in the identification of obstructive coronary artery disease

Background We measured myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) by a dynamic low-dose CZT-SPECT protocol in patients with suspected or known coronary artery disease (CAD) and investigated the capability of dynamic data in predicting obstructive CAD. A total of 173 patients...

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Veröffentlicht in:	European journal of nuclear medicine and molecular imaging 2020-07, Vol.47 (7), p.1705-1712
Hauptverfasser:	Acampa, Wanda, Assante, Roberta, Mannarino, Teresa, Zampella, Emilia, D’Antonio, Adriana, Buongiorno, Pietro, Gaudieri, Valeria, Nappi, Carmela, Giordano, Alessia, Mainolfi, Ciro Gabriele, Petretta, Mario, Cuocolo, Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Angiography Blood flow Blood vessels Cardiology Cardiovascular disease Coronary Angiography Coronary artery Coronary artery disease Coronary Artery Disease - diagnostic imaging Coronary vessels Heart diseases Humans Imaging Medical imaging Medicine Medicine & Public Health Middle Aged Myocardial Perfusion Imaging - instrumentation Myocardial Perfusion Imaging - methods Nuclear Medicine Oncology Original Article Orthopedics Perfusion Radiology Regional analysis Single photon emission computed tomography Stenosis Technetium Tc 99m Sestamibi Tomography Tomography, Emission-Computed, Single-Photon
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Zusammenfassung:	Background We measured myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) by a dynamic low-dose CZT-SPECT protocol in patients with suspected or known coronary artery disease (CAD) and investigated the capability of dynamic data in predicting obstructive CAD. A total of 173 patients with suspected or known CAD underwent dynamic CZT-SPECT after the injection of 155 MBq and 370 MBq of 99m Tc-sestamibi for rest and stress imaging, respectively. Standard rest and stress imaging were performed at the end of each dynamic scan. A total perfusion defect (TPD)
ISSN:	1619-7070 1619-7089
DOI:	10.1007/s00259-019-04644-6