Integrated Microstructured Photonic Fiber as a Bifunctional Robust Frit and Efficient Electrospray Emitter of a Packed Column for Capillary Liquid Chromatography–Tandem Mass Spectrometry Analysis of Complex Biological Samples

Although capillary liquid chromatography married with tandem mass spectrometry (cLC–MS/MS) has become a powerful technique for proteomics and metabolomics research, it is still a great challenge to fabricate durable capillary-based analytical columns coupling continuous nanoflow (100), which always encumbers both independent and integral tapered tip emitters for cLC–MS.